Justicidin C
CAS.NO: 17803-12-2 Category: Vesicular stomatitis virus (VSV) Mol. Formula: C22H18O7 Mol. Wt.: 394.37
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| Synonyms | Justicidin C;NEOJUSTICIN B;17803-12-2;UNII-X97477NS3D;X97477NS3D;Naphtho(2,3-c)furan-1(3H)-one, 4-(1,3-benzodioxol-5-yl)-6,7,9-trimethoxy-;Naphtho(2,3-c)furan-1(3H)-one, 6,7,9-trimethoxy-4-(3,4-(methylenedioxy)phenyl)-;9-(1,3-benzodioxol-5-yl)-4,6,7-trimethoxy-1H-benzo[f][2]benzofuran-3-one;Justicindin A;Naphtho[2,3-c]furan-1(3H)-one, 4-(1,3-benzodioxol-5-yl)-6,7,9-trimethoxy-;CHEMBL455623;SCHEMBL15920775;DTXSID40170413;RHTTTZYNBXNPSZ-UHFFFAOYSA-N;Q27293719;9-(1,3-benzodioxol-5-yl)-4,6,7-trimethoxy-1H-benzo[f]isobenzofuran-3-one;4-(benzo[d][1,3]dioxol-5-yl)-6,7,9-trimethoxynaphtho[2,3-c]furan-1(3H)-one; |
| IUPAC Name | 9-(1,3-benzodioxol-5-yl)-4,6,7-trimethoxy-1H-benzo[f][2]benzofuran-3-one |
| SMILES | O=C1OCC2=C(C3=CC=C(OCO4)C4=C3)C5=CC(OC)=C(OC)C=C5C(OC)=C12 |
| InChI | InChI=1S/C22H18O7/c1-24-16-7-12-13(8-17(16)25-2)21(26-3)20-14(9-27-22(20)23)19(12)11-4-5-15-18(6-11)29-10-28-15/h4-8H,9-10H2,1-3H3 |
| InChI Key | RHTTTZYNBXNPSZ-UHFFFAOYSA-N |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Drug Resistance | Drug resistance mechanism: Justicidin C targets the inhibition of specific proteins, disrupting the cellular processes essential for pathogen survival, potentially involving genes that alter drug uptake or efflux. Common mutations: Mutations in the target gene region can lead to amino acid substitutions, reducing drug binding affinity and causing resistance to Justicidin C. Drug resistance-related sites: Alterations at binding sites, such as the ATP-binding cassette, may confer resistance by modifying the drug's interaction with its target. Cross-resistance situations: Resistance to Justicidin C may confer cross-resistance to other drugs targeting similar pathways due to shared resistance mechanisms. Monitoring suggestions: Regularly sequence the target gene to detect mutations that could indicate emerging resistance. |
| Applications | Antiviral Research: Justicidin C exhibits potent inhibitory effects on various viral strains, offering significant potential in antiviral drug development. Viral Replication Inhibition: This compound disrupts viral replication processes, making it a promising candidate for therapeutic interventions. Molecular Studies: Justicidin C is valuable for understanding viral mechanisms, aiding in the design of targeted antiviral strategies. Pharmaceutical Formulations: Its unique properties facilitate the development of innovative antiviral formulations, enhancing market competitiveness. Biotechnological Applications: The compound's versatility supports its use in biotechnological advancements, expanding its application range in antiviral research. |
| Protocol Notes | Storage Conditions: Store Justicidin C at -20℃. Ensure the product is kept in a tightly sealed container to prevent degradation and maintain its efficacy. Solution Preparation: Dissolve Justicidin C in DMSO. Use an appropriate solvent to achieve the desired concentration for experimental applications. Operation Precautions: Handle Justicidin C with care. Utilize personal protective equipment to avoid direct contact and inhalation during handling. Stability Monitoring: Regularly check Justicidin C for changes. Monitor for any color change or precipitation, indicating potential degradation. Light Sensitivity: Protect Justicidin C from light exposure. Use amber vials or foil wrapping to prevent photodegradation and ensure product stability. |
| Drug Combination | Purpose of Combination: Enhance therapeutic efficacy. Combining Justicidin C with other agents aims to improve overall treatment outcomes by leveraging synergistic effects. Combination Strategies: Synergistic agents. Justicidin C is often combined with other bioactive compounds to potentiate its anticancer properties and reduce tumor growth. Drug Interactions: Monitor potential interactions. When used in combination, Justicidin C can interact with other drugs, necessitating careful monitoring to avoid adverse effects. Pharmacokinetic Considerations: Consider absorption rates. The absorption and metabolism of Justicidin C may be altered in combination therapies, impacting its bioavailability and efficacy. Research Focus: Explore novel combinations. Encouraging scientific exploration of Justicidin C combinations can lead to innovative treatments and a deeper understanding of its mechanisms. |
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
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Date: 11/1/2024
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Date: 1/1/2024
Encapsulated vitamin d
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