Octyl Gallate
CAS.NO: 1034-01-1 Category: Herpes simplex Virus (HSV) Mol. Formula: C15H22O5 Mol. Wt.: 282.33
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Description: Octyl Gallate is an octyl ester of gallic acid that is commonly used as a food preservative such as a thickener, bulking agent, or emulsifier in processed foods. Octyl Gallate exhibits antifungal activity against Zygosaccharomyces bailii, Aspergillus niger, Candida albicans, and Saccharomyces cerevisiae, as well as antibacterial and antiviral activities against Enterococcus facealis, poliovirus herpes simplex virus type 1, and stomatitis virus.
| Synonyms | n-Octyl gallate; Progallin O; Stabilizer GA 8 |
| IUPAC Name | octyl 3,4,5-trihydroxybenzoate |
| SMILES | CCCCCCCCOC(=O)C1=CC(=C(C(=C1)O)O)O |
| InChI | InChI=1S/C15H22O5/c1-2-3-4-5-6-7-8-20-15(19)11-9-12(16)14(18)13(17)10-11/h9-10,16-18H,2-8H2,1H3 |
| InChI Key | NRPKURNSADTHLJ-UHFFFAOYSA-N |
| Boiling Point | 482.9±40.0 °C at 760 mmHg |
| Melting Point | 101-104 °C (lit.) |
| Flash Point | 177.1±20.8 °C |
| Density | 1.2±0.1 g/cm3 |
| Solubility | Soluble in methanol. |
| Appearance | White to off-white solid |
| Complexity | 269 |
| Exact Mass | 282.14672380 |
| Index Of Refraction | 1.552 |
| Vapor Pressure | 0.0±1.3 mmHg at 25°C |
| PSA | 86.99000 |
| XLog P3 AA | 3.7 |
| Storage | 2-8 °C |
| Purity | 99.96% |
| In Vitro | Octyl gallate has antimicrobial activity over H. pylori, with a minimum inhibitory concentration (MIC) value of 125 µg/mL. |
| In Vivo | Octyl gallate has antimicrobial activity over H. pylori, with a minimum inhibitory concentration (MIC) value of 125 µg/mL. |
| Target | Bacterial; HSV; Influenza Virus; Reactive Oxygen Species |
| Drug Resistance | Resistance mechanism: Octyl Gallate resistance emerges through oxidative-stress pathway adjustments reducing compound disruption of redox balance. Common mutations: Alterations in antioxidant-regulating enzymes attenuate susceptibility. Cross-resistance: Observed among redox-modulating agents acting on related regulatory pathways. Monitoring suggestion: Sequence oxidative-stress pathway genes for adaptive variants. |
| Applications | Phenolic Antiviral Mechanistic Studies: Octyl Gallate alters oxidative and membrane-associated pathways influencing viral replication. Redox-State Regulation Research: Useful for profiling oxidative-stress–driven antiviral responses. Membrane Perturbation Studies: Applied to evaluate lipid-dependent viral entry inhibition. Broad Mechanistic Screening: Supports multi-pathway antiviral evaluation. Chemical Probe Applications: Enables targeted exploration of redox and membrane biology. |
| Protocol Notes | Storage: Maintain Octyl Gallate at 4°C in tightly sealed containers to prevent oxidation. Solution Preparation: Dissolve in ethanol or DMSO with mild heating if needed. Handling Notes: Limit air exposure to minimize auto-oxidative degradation. Light Notes: Store solutions in amber vials to avoid photochemical changes. Stability: Replace stocks regularly to ensure consistent antioxidant activity. |
| Drug Combination | Purpose: Enhance antioxidant and anti-inflammatory properties. Combination Strategies: Often used in combination with other antioxidants or anti-inflammatory agents to enhance cellular protection in oxidative stress models. Considerations: Assess its potential to interfere with cellular signaling pathways and redox balance in experimental systems. |
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Targeted inhibition of gut bacterial β-glucuronidases by octyl gallate alleviates mycophenolate mofetil-induced gastrointestinal toxicity
Journal: International Journal of Biological Macromolecules
Date: 4/1/2024
Octyl gallate has potent anti‐inflammasome activity by directly binding to NLRP3 LRR domain
Journal: Journal of Cellular Physiology
Date: 1/19/2024
Antimicrobial activity of octyl gallate nanoemulsion combined with photodynamic technology and its effect on food preservation
Journal: International Journal of Food Microbiology
Date: 2/2/2025
Ascorbic acid potentiates photodynamic inactivation mediated by octyl gallate and blue light for rapid eradication of planktonic bacteria and biofilms
Journal: Food Chemistry
Date: 8/1/2024
Still have questions?
