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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
Penciclovir
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| Category | Herpes simplex Virus (HSV) |
| CAS | 39809-25-1 |
| Description | Penciclovir is a guanosine analogue antiviral drug used for the treatment of various herpesvirusinfections. It is a nucleoside analogue which exhibits low toxicity and good selectivity. |
Product Information
| Synonyms | BRL-39123; BRL 39123; BRL39123; VSA 671; VSA671; VSA-671; Penciclovir; Denavir, Vectavir and Fenivir. |
| IUPAC Name | 2-amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-1H-purin-6-one |
| Molecular Weight | 253.26 |
| Molecular Formula | C10H15N5O3 |
| Canonical SMILES | C1=NC2=C(N1CCC(CO)CO)NC(=NC2=O)N |
| InChI | InChI=1S/C10H15N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)2-1-6(3-16)4-17/h5-6,16-17H,1-4H2,(H3,11,13,14,18) |
| InChIKey | JNTOCHDNEULJHD-UHFFFAOYSA-N |
| Boiling Point | 636.7±65.0 °C at 760 mmHg |
| Melting Point | 275-277°C |
| Flash Point | 338.9±34.3 °C |
| Purity | >98% |
| Density | 1.7±0.1 g/cm3 |
| Solubility | In Vitro: DMSO: ≥ 53 mg/mL (209.27 mM) |
| Appearance | White to off-white (Solid) |
| Application | Antiviral agents; reverse transcriptase inhibitors |
| Storage | Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month |
| Complexity | 344 |
| Exact Mass | 253.11748936 |
| Index Of Refraction | 1.749 |
| In Vitro | Penciclovir (PCV) is an acyclic guanine derivative, and has a spectrum of activity and a mechanism of action similar to those of acyclovir (ACV). Penciclovir inhibits herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), varicella-zoster virus (VZV), epstein-Barr virus (EBV), human cytomegalovirus (HCMV) with IC50 of 0.04-1.8 μg/mL, 0.06-4.4 μg/mL,1.6-8 μg/mL, 1.5-3.1 μg/mL, 51 μg/mL, respectively. |
| In Vivo | Penciclovir (100 mg/kg; s.c.; daily for 5 days) preventes mortality in mouse. |
| PSA | 130.05000 |
| Target | HSV, IC50: 0.04-1.8 μg/mL (HSV-1), 0.06-4.4 μg/mL (HSV-2), 1.6-8 μg/mL (VZV), 1.5-3.1 μg/mL (EBV), 51 μg/mL (HCMV) |
| Vapor Pressure | 0.0±2.0 mmHg at 25°C |
| XLogP3-AA | -1.9 |
