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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
Kushenol K
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| Category | Herpes simplex Virus (HSV) |
| CAS | 101236-49-1 |
| Description | Kushenol K is extracted from the root of Sophora flavescens Ait. It showed weak antiviral activity against Herpes simplex virus types I and II. It is a potent and selective Inhibitor of cGMP Phosphodiesterase 5. It was investigated for their inhibitory effects on diacylglycerol acyltransferase (DGAT). |
Product Information
| Synonyms | Kushenol K|101236-49-1 |
| IUPAC Name | (2R,3S)-2-(2,4-dihydroxyphenyl)-3,7-dihydroxy-8-[(2R)-5-hydroxy-5-methyl-2-prop-1-en-2-ylhexyl]-5-methoxy-2,3-dihydrochromen-4-one |
| Molecular Weight | 472.527 |
| Molecular Formula | C26H32O8 |
| Canonical SMILES | CC(=C)C(CCC(C)(C)O)CC1=C2C(=C(C=C1O)OC)C(=O)C(C(O2)C3=C(C=C(C=C3)O)O)O |
| InChI | InChI=1S/C26H32O8/c1-13(2)14(8-9-26(3,4)32)10-17-19(29)12-20(33-5)21-22(30)23(31)25(34-24(17)21)16-7-6-15(27)11-18(16)28/h6-7,11-12,14,23,25,27-29,31-32H,1,8-10H2,2-5H3/t14-,23-,25-/m1/s1 |
| InChIKey | YWHHRFNOJTVNBI-LBEFLKDASA-N |
| Boiling Point | 722.4±60.0 °C at 760 mmHg |
| Flash Point | 242.4±26.4 °C |
| Purity | >98% |
| Density | 1.3±0.1 g/cm3 |
| Solubility | Soluble in DMSO |
| Appearance | Crystalline |
| Application | antiviral/inhibitors |
| Storage | Store at -20°C |
| Complexity | 724 |
| Exact Mass | 472.20971797 |
| Index Of Refraction | 1.614 |
| In Vitro | When Midazolam is used as the substrate of CYP3A4, Kushenol K exhibits the strong inhibition with an IC50 values of 1.62 µM. At a concentration of 50 μM, the inhibition rate of Kushenol K on SGLT1 is 29.7%, and the inhibition rate on SGLT2 is 43.7%. |
| Target | HSV-2:147 μM (EC50) CYP3A4:1.35 μM (Ki) SGLT |
| Vapor Pressure | 0.0±2.5 mmHg at 25°C |
| XLogP3-AA | 3.7 |