Influenza-A-virus-IN-8

Category	Influenza Virus
Description	Influenza A virus-IN-8 (S5) is a macrocyclic peptide with no cytotoxic. Influenza A virus-IN-8 is also a potent Influenza A Virus (IAV) inhibitor (with sufficient protease stability) with IC50s of 6.7 and 6.6 nM for H1 and H5 variants, respectively. Influenza A virus-IN-8 shows good affinitiescan to H1 variants, binds to a conserved region in the HA stem with a Kd of 1.0 nM.

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Synonyms	Influenza A virus-IN-8\|CS-0566212
Molecular Weight	2200.48
Molecular Formula	C104H142N28O24S
Canonical SMILES	CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)N1)CC(C)C)C(C)O)CC2=CN=CN2)CC(=O)O)CC3=CNC4=CC=CC=C43)CCCNC(=N)N)CC5=CC=CC=C5)CC(C)C)C(C)C)CC6=CC=C(C=C6)O)C(=O)NCC(=O)N)C(C)C)CC7=CNC8=CC=CC=C87)CC9=CN=CN9)C(C)O
Purity	≥98% (HPLC)
Solubility	In vitro: 10 mM in DMSO
Appearance	Solid powder
Storage	Store at -20°C
Complexity	4840
Exact Mass	2200.0506035
In Vitro	Influenza A virus-IN-8 (5 μM; 72 h) does not affect viability of HeLa and MDCKI cells. Influenza A virus-IN-8 (5 μM; 24 h) shows neutralizing effect on H1N1pdm09 and H5N1 in a dose-dependent manner. Influenza A virus-IN-8 (5 nM; 2 h) binds to a conserved region in the HA stem with Kd of 1.0 nM for H1 variants. Influenza A virus-IN-8 (5 μM; 1 h) inhibits HA fusion activity during entry by stabilizing the prefusion conformation.
In Vivo	Influenza A virus-IN-8 (5 μM; 72 h) does not affect viability of HeLa and MDCKI cells.
Target	Influenza Virus
XLogP3-AA	2.4