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Ganciclovir

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Category Cytomegalovirus (CMV)
CAS 82410-32-0
Description Ganciclovir is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM.
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Product Information

Synonyms Cytovene; BW 759; BW759; BW-759; 2'-Nor-2'-deoxyguanosine
IUPAC Name 2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-1H-purin-6-one
Molecular Weight 255.23
Molecular Formula C9H13N5O4
Canonical SMILES C1=NC2=C(N1COC(CO)CO)NC(=NC2=O)N
InChI InChI=1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)
InChIKey IRSCQMHQWWYFCW-UHFFFAOYSA-N
Boiling Point 675°C at 760 mmHg
Melting Point 251-252°C
Purity >98%
Density 1.81 g/cm3
Solubility Soluble in DMSO
Appearance White Solid
Application Antiviral agents
Storage Store at -20°C
Animal Admin Two albino rats non-immunized for MCMV are used in the study. The first rat receives 50 mg/kg of ganciclovir twice a day (i.e. 100 mg/kg/day), for a total of 3 days or 6 injections. The second rat is used as a negative control and received intraperitoneal injections of glucose solution. Ganciclovir is diluted in 5% glucose serum to a concentration of 5 mg/mL and administered intraperitoneally in newborn mice at a dose of 50 mg/kg twice a day. Five injections are administered in total.
Complexity 346
Exact Mass 255.09675391
In Vitro Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain.
In Vivo In adult rats, the intracochlear diffusion of ganciclovir is shown to achieve the same concentration as in blood. In newborn mice, the plasma concentration profile of ganciclovir shows a peak at 2 h followed by a gradual decrease. In adult mice, the concentration peaked at 1 h, but becomes undetectable by 2 h after injection. Counts of white blood cells, red blood cells and platelets decreases significantly in ganciclovir-treated newborn mice.
PSA 53.99000
Target CMV; HSV; Antibiotic; Nucleoside Antimetabolite/Analog. IC50: 5.2 μM (FHV-1)
XLogP3-AA -2.5

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