Pentosan Polysulfate Sodium

Category	Human immunodeficiency Virus (HIV)
CAS	140207-93-8
Description	Pentosan polysulfate sodium is a biomedical product used for treating interstitial cystitis, a chronic bladder condition causing pain and frequent urination. This compound acts as an anticoagulant and a urinary protectant, reducing inflammation and restoring the integrity of the bladder lining.

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Synonyms	4-O-Methyl-α-D-glucurono-β-D-xylan, hydrogen sulfate, sodium salt; Cartrophen; CB 8061; Elmiron; Fibrase; Fibrezym; Hemoclar; HOE/BAY 946; Pentosan polysulfate sodium salt; PPS; PZ 68; Sodium pentosan polysulfate; SP 54; Thrombocid
Molecular Formula	(C32H38Na12O59S11)n
Solubility	Soluble in DMSO (10 mM)
Appearance	White to Off-white Solid
Storage	Keep container tightly closed in a dry and well-ventilated place.
In Vitro	Pentosan Polysulfate Sodium has been shown to inhibit HIV-1 activity with an ED50 of 0.19 μg/mL in MT-4 cells. It inhibits HIV-1 antigen expression in HUT-78 cells at an ED50 of 0.02 μg/mL, and complete inhibition of HIV-1 antigen expression is obtained at a concentration of 4.0 μg/mL. Pentosan Polysulfate Sodium suppresses NF-κB, decreases the proinflammatory actions of TNFα, and decreases high glucose and advanced glycation end products (AGEs) stimulated MCP-1 production.
In Vivo	Pentosan Polysulfate Sodium has been shown to decreases interstitial inflammation and glomerulosclerosis in 5/6 nephrectomized rats. Pentosan polysulfate treatment preserves renal function, significantly reduces albuminuria, and markedly decreases the severity of renal lesions, including tubulointerstitial inflammation. Pentosan Polysulfate Sodium also reduces upregulation of TNFα and proinflammatory genes in aging diabetic kidneys.
Target	HIV