SARS-CoV

all Chemical (1) Inhibitors (588) Modulators (2)

CAS No.	Product Name	Inquiry
1416992-39-6	GC376 sodium GC376 is a 3CLpro inhibitor which is previously reported to be active against the 3CLpro of multiple coronaviruses, including SARS-CoV, but with highest potency against FIPV in cell culture. GC376 inhibits the replication of viruses TGEV, FIPV and PTV with IC50 values of 0.15, 0.2 and 0.15 μM.
34031-32-8	Auranofin Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA, as an inhibitor of thioredoxin reductase (TrxR) (IC50 = 20 nM; Ki = 4 nM for the NADPH-reduced form of human cytosolic TrxR).
700361-47-3	Rilpivirine Hydrochloride Rilpivirine, also known as TMC278, is a drug used as a part of antiretroviral therapy (ART). Rilpivirine is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) with higher potency, longer half-life and reduced side-effect profile compared with older NNRTIs.
152459-95-5	Imatinib Imatinib inhibits the SLF-dependent activation of wild-type c-kit kinase activity with an IC50 for these effects of approximately 0.1 μM, which is similar to the concentration required for inhibition of PDGFR. Imatinib is an oral chemotherapy agent used to treat cancers. Specifically, it is used for chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL) that are Philadelphia chromosome-positive (Ph+), certain types of gastrointestinal stromal tumors (GIST), hypereosinophilic syndrome (HES), chronic eosinophilic leukemia (CEL), systemic mastocytosis, and myelodysplastic syndrome.
518-82-1	Emodin Emodin is an anthraquinone found naturally in the roots and barks of numerous plants. It exerts antiproliferative effects in cancer cells that are regulated by different signaling pathways. It has anti-cancer, anti-depressant and anti-microbial effects.
1177-87-3	Dexamethasone acetate (Standard) The acetate-protect form of Dexamethasone which is a glucocorticoid and could be used as an anti-inflammatory agent. It can be used for various inflammations, allergic diseases, bovine ketoneemia, sheep pregnancy toxemia, and can also be used for the simultaneous delivery of female animals.
147821-57-6	Niazinin Niazinin is a natural compound isolated from the leaves of Moringa oleifera Lam, showing antileishmanial activity against promastigotes of Leishmania donavani.
65995-63-3	Punicalagin Punicalagin is an ellagitannin, a type of phenolic compounds. It had a greater antifungal activity against T. rubrum. It has the potential to be developed as an alternative or supplemental agent for prevention of Salmonella infection. After being absorbed by the human body, punicalagin can be decomposed into ellagic acid under the action of human enzymes. It has excellent antioxidant properties and has been used as a food antioxidant. It is now mostly used in cosmetics.
548-37-8	Verbenalin Cornin has protective potential against cerebral ischemia injury and its protective effects may be due to amelioration of cerebral mitochondrial function and its antioxidant property.
105351-70-0	Tanshinlactone Tanshinlactone is a natural diterpenoid found in Salvia miltiorrhiza.
197781-85-4	Bonducellpin D Bonducellpin D is a natural diterpenoid compound found in several plants.
5508-58-7	Andrographolide Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata. It has the effects of dispelling heat, detoxification, anti-inflammatory and relieving pain.
20784-60-5	1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one 4'-O-Methylbroussochalcone B is a natural chalcone found in the seeds of Psoralea corylifolia Linn.
481-49-2	Cepharanthine Cepharanthine (CEP) is a biscoclaurine alkaloid isolated from Stephania cepharantha. It has anticancer, antiinflammatory, antiallergic, immunomo- dulatory, and many other interesting biological activities. Cepharanthine has been widely used in Japan for more than 40 years to treat a wide variety of acute and chronic diseases. CEP inhibits tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and suppresses cytokine production. It has also been shown to scavenge free radicals and to have a protective effect against some of the responses mediated by pro-inflammatory cytokines such as TNF-α, interleukin (IL)-1β and IL6. CEP has successfully been used to treat a diverse range of medical conditions, including radiation-induced leukopenia, idiopathic thrombocytopenic purpura, alopecia areata, alopecia pityrodes, venomous snakebites, xerostomia, sarcoidosis, refractory anemia and various cancer-related conditions. No safety issues have been observed with CEP, and side effects are very rarely reported.
50-63-5	Chloroquine phosphate Chloroquine phosphate is an antimalarial drug and weak intercalating agent. It inhibits TLR signalling in plasmacytoid dendritic cells (pDCs). It has been used in emergency of COVID-19.
747-36-4	Hydroxychloroquine Sulfate Hydroxychloroquine Sulfate is an autophagy inhibitor that induces autophagic cell death. It also inhibits TLR9. Hydroxychloroquine is an antimalarial drug, and in combination with other medications, it can be used in the treatment of some autto-immune diseases. It has been used in emergency of COVID-19.
34580-14-8	Ketotifen Fumarate Ketotifen is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer. It is most commonly sold as a salt with fumaric acid, ketotifen fumarate, and is available in two forms. In its ophthalmic form, it is used to treat allergic conjunctivitis,or the itchy red eyes caused by allergies. In its oral form, it is used to preventasthma attacks.
99011-02-6	Imiquimod An agonist of TLR7 with immune response modifying activity, Approved for basal cell carcinoma, In Phase III for VIN and CIN, Imiquimod's proapoptotic activity appears to be related to Bcl-2 overexpression in susceptible tumor cells.
79307-93-0	Azelastine HCl Azelastine HCl is a potent, second-generation, selective, histamine antagonist. It inhibits histamine via competing with histamine for the H1 receptor.
131707-23-8	Arbidol hydrochloride Arbidol is an antiviral agent used for the treatment of influenza infection in Russia and China. It has been used against influenza A and B viruses, and hepatitis C virus (HCV). It has been shown that ARB could inhibit COVID-19 infection through interfering the release of SARS-CoV-2 from intracellular vesicles. It can be used to treat trypanosomiasis in livestock.

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