Reverse Transcriptases (RTs)

CAS No.	Product Name	Inquiry
	(+/-)-Epigallocatechin Gallate-13C3
1436383-95-7	BF738735 A potent and selective ATP-competitive phosphatidylinositol 4-kinase III beta (PI 4-KIIIβ) inhibitor (IC50 = 5.7 nM). Displays approximately 200-fold selectivity over PI 4-KIIIα. Broad spectrum enterovirus replication inhibitor.
	C34 peptide
	EFdA-TP tetraammonium EFdA-TP tetraammonium is a potent inhibitor of nucleoside reverse transcriptase (RT). It inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP tetraammonium inhibits HIV-1 RT with multiple mechanisms.
	EFdA-TP tetralithium
1018450-26-4	Fosdevirine Fosdevirine is a highly potent next-generation Anti-HIV nonnucleoside reverse transcriptase inhibitor (NNRTI) with an EC50 of 11 nM. It is a novel and once-daily (QD) inhibitor with activity against efavirenz-resistant strains. It demonstrated potent antiviral activity in treatment-naive HIV-infected subjects, and had favorable PK and resistance profiles. It was originally developed by idenix pharmaceuticals and was in clinical phase 2, but now it has been terminated.
1051418-95-1	Nevirapine-[d4] Nevirapine-[d4] is the labelled analogue of Nevirapine, which is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.
1051419-24-9	Nevirapine-[d3] Nevirapine-[d3] is the labelled analogue of Nevirapine. Nevirapine is an anti-HIV drug that reduces the amount of virus in the body.
106941-25-7	Adefovir Used as an antiviral.
1096687-52-3	SPK-601 SPK-601 is a potent phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor,a useful antimicrobial agent.
1132642-95-5	Efavirenz-[d5] Efavirenz-[d5] is the labelled analogue of Efavirenz. Efavirenz is an antiretroviral medication used to treat and prevent HIV/AIDS.
1142096-06-7	Etravirine-[d6] Etravirine-[d6] is the labelled analogue of Etravirine. Etravirine is a drug used for the treatment of HIV. Etravirine is a non-nucleoside reverse transcriptase inhibitor.
1219803-67-4	Stavudine-[d4] An isotope labelled Stavudine. Stavudine is an antiretroviral medication used to prevent and treat HIV/AIDS.
122525-61-5	Protorubradirin
1236287-04-9	Tenofovir maleate Tenofovir hydrate reduces the viral cytopathic effect of HIV-1(IIIB), HIV-2(ROD) and HIV(EHO) with EC50 of 1.15 μg/mL, 1.12 μg/mL and 1.05 μg/mL in MT-4 cells. Tenofovir hydrate also reduces the viral cytopathic effect of SIV(mac251) , SIV(B670) ,SHIV(89.6) and SHIV(RTSHIV). Tenofovir hydrate inhibits hepatitis B virus (HBV) activity in HepG2 2.2.15, HepAD38 and HepAD79 cells. Tenofovir hydrate (4 μM) completely inhibits the growth of HIVIIIB in MT-2 cells. Tenofovir hydrate inhibits synthesis of negative strand strong-stop DNA with IC50 of 9 ?M for wild-type RT, 6 ?M for M184V RT and 50 ?M for K65R RT. Tenofovir hydrate (30 mg/kg) completely prevents SIV infection in all macaques without toxicity. Tenofovir hydrate treatment reduces plasma viral RNA levels to undetectable, with parallel decreases in the infectivity of plasma and infectious cells in peripheral blood mononuclear cells and cerebrospinal fluid (CSF) and stabilization of CD4+ T-cell numbers. Tenofovir hydrate (30 mg/kg, s.c.) completely abrogates HIV infection via intravaginal exposure in pig-tailed macaques.
1246812-58-7	rac Efavirenz-[d4] Rac Efavirenz-[d4] is an isotope compound of rac Efavirenz. Efavirenz is an NNRTI that prevents RNA plus-strand initiation with an IC50 value of 17 nM. Efavirenz also inhibits the late stages of HIV-1 replication by interfering with HIV-1 Gag-Pol polyprotein processing. It has been used in combination therapy with drugs directed at the treatment of opportunistic infections such as HIV and cancer.
1246818-16-5	Pyridoxal-[d5] 5'-phosphate An isotope labelled Pyridoxal phosphate. Pyridoxal phosphate is the active form of vitamin B6. It is a coenzyme in a variety of enzymatic reactions.
1261394-62-0	Efavirenz-[13C6] Efavirenz-[13C6], is the labelled analogue of Efavirenz. Efavirenz is an antiretroviral medication used to treat and prevent HIV/AIDS.
126320-77-2	R-82150
129-46-4	Suramin Sodium The sodium salt of Suramin which is a P2 purinergic antagonist and has been also found to have the effect in blocking the G protein binds to GPCRs so that it was studied the activity against sorts of cancer cell lines.

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