Reverse Transcriptases (RTs)

CAS No.	Product Name	Inquiry
1246818-16-5	Pyridoxal-[d5] 5'-phosphate An isotope labelled Pyridoxal phosphate. Pyridoxal phosphate is the active form of vitamin B6. It is a coenzyme in a variety of enzymatic reactions.
1261394-62-0	Efavirenz-[13C6] Efavirenz-[13C6], is the labelled analogue of Efavirenz. Efavirenz is an antiretroviral medication used to treat and prevent HIV/AIDS.
129-46-4	Suramin Sodium The sodium salt of Suramin which is a P2 purinergic antagonist and has been also found to have the effect in blocking the G protein binds to GPCRs so that it was studied the activity against sorts of cancer cell lines.
129618-40-2	Nevirapine Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.
1312424-26-2	Rilpivirine-[d6] Rilpivirine-[d6] is the labelled analogue of Rilpivirine. Rilpivirine ia a novel non-nucleoside reverse transcriptase inhibitor. Rilpivirine seems to be well tolerated with less CNS disturbance than Efavirenz, and has non-teratogenic potential. An anti-HIV agent.
1329613-10-6	Dapivirine-[d11] Dapivirine-[d11], is the labelled analogue of Dapivirine. Dapivirine is a NNRTI for HIV reverse transcriptase with IC50 of 24 nM, inhibiting a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates.
1333126-31-0	Azvudine hydrochloride Azvudine hydrochloride is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine hydrochloride inhibits NRTI-resistant viral strains.
134379-77-4	2',3'-Dideoxy-2',3'-didehydro-5-fluoro-cytidine It is a nucleoside reverse transcriptase inhibitor (NRTI) with the potential to inhibit HIV-1 replication.
134624-73-0	Stavudine sodium Stavudine sodium is a dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. Stavudine sodium is an analog of thymidine. It is phosphorylated by cellular kinases into active triphosphate. Stavudine sodium triphosphate inhibits the HIV reverse transcriptase by competing with natural substrate, thymidine triphosphate. It also causes termination of DNA synthesis by incorporating into it. Mice were treated for 2 weeks with stavudine d4T (500 mg/kg/day), L-carnitine (200 mg/kg/day) or both drugs concomitantly. Body fatness was assessed by dual energy X-ray absorptiometry, and investigations were performed in plasma, liver, muscle and WAT. D4T reduced the gain of body adiposity, WAT leptin, whole body FAO and plasma ketone bodies, and increased liver triglycerides and plasma aminotransferases with mild ultrastructural abnormalities in hepatocytes.
136817-59-9	Delavirdine Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). It is used as part of highly active antiretroviral therapy (HAART) for the treatment of human immunodeficiency virus (HIV) type 1.
1391052-30-4	Lamivudine-13C-15N2 Lamivudine 13C,15N2 is a labelled impurity of Lamivudine (BCH-189). Lamivudine is a nucleoside reverse transcriptase inhibitors (NRTIs), and can inhibit HIV reverse transcriptase 1/2 and the reverse transcriptase of hepatitis B virus.
145-63-1	Suramin Suramin, also called as Germanin, has been demonstrated to inhibit a large variety of enzymes including urease, hexokinase, succinic dehydrogenase, p-glucuronidase, acid phosphatase, lysozyme, thrombin, plasma kallikrein, (Na'-K')-activated ATPase, plasmi
147127-20-6	Tenofovir Tenofovir blocks reverse transcriptase and hepatitis B virus infections.
147362-57-0	Loviride Loviride is an RNA-directed DNA polymerase inhibitor potentially for the treatment of HIV infection.
154598-52-4	(S)-6-Chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are highly specific and potent allosteric inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. Efavirenz is an NNRTI that prevents RNA plus-strand initiation with an IC50 value of 17 nM. Efavirenz also inhibits the late stages of HIV-1 replication by interfering with HIV-1 Gag-Pol polyprotein processing. It has been used in combination therapy with drugs directed at the treatment of opportunistic infections such as HIV and cancer.
1591823-76-5	Ulonivirine Ulonivirine (MK-8507) is an orally active non-nucleoside reverse transcriptase inhibitor with high antiviral activity.
166403-66-3	Tenofovir Diphosphate The diphosphate salt form of Tenofovir, which is an acyclic phosphonate nucleotide derivative, could be used in antiviral treatment as an everse transcriptase inhibitor.
173522-96-8	Lamivudine Salicylate Lamivudine Salicylate is used in the synthesis of Lamivudine, which is a potent nucleoside reverse transcriptase inhibitor and antiviral agent used to treat chronic hepatitis B.
201341-05-1	Tenofovir Disoproxil Tenofovir dsoproxil is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B.
206184-49-8	Tenofovir hydrate Tenofovir(GS 1278, PMPA) is an antiretroviral drug known as nucleotide analogue reverse transcriptase inhibitors (NRTIs), which block reverse transcriptase, a crucial virus enzyme in HIV-1 and HBV.

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