Human immunodeficiency Virus (HIV)

CAS No.	Product Name	Inquiry
5496-35-5	I-XW-053 I-XW-053 is an inhibitor of capsid targeted HIV-1 replication using the hybrid structure based method to block the interface between CA N-terminal domains (NTD-NTD interface) with micromolar affinity.
55497-79-5	Myriceric acid B Myriceric acid B isolated from the root bark of Myrica cerifera L. It exhibits cytotoxic activity towards the MOLT-3 cell line.
558447-26-0	AMD-070 AMD-070 is a potent and selective antagonist of CXCR4 (with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay).
55954-61-5	Pseudohypericin Pseudohypericin, which can be found in the herbs of Hypericum perforatum L, is implicated in the antidepressant efficacy of St. John's wort.
561022-65-9	Alloc-DOX
56317-05-6	Kaempferol-3-O-(6′′-galloyl)-β-glucopyranoside
582-24-1	2-Hydroxyacetophenone 2-Hydroxyacetophenone (CAS# 582-24-1) is a useful reactant for synthesis of diarylpyrazoles as cyclooxygenase 2 inhibitors.
583836-55-9	Cys-TAT (47-57) It is an arginine-rich cell-penetrating peptide derived from HIV-1 transactivator protein.
59-48-3	Diclofenac EP Impurity E Diclofenac EP Impurity E is an impurity of Diclofenac, which is a non-selective COX inhibitor used as a non-steroidal anti-inflammatory drug (NSAID).
5948-75-4	gp120-IN-1 gp120-IN-1 (compound 4e) is a potent HIV-1 gp120 inhibitor with an IC50 of 2.2 µM and CC50 of 100.90 µM. gp120-IN-1 shows anti-HIV-1 activity. gp120-IN-1 shows cytotoxicity in a dose dependent manner in SUP-T1 cells. gp120-IN-1 shows inhibition of gp120-mediated virus enter into cells.
595-33-5	Medroxyprogesterone Acetate EP Impurity G Medroxyprogesterone Acetate EP Impurity G is a synthetic progesteronal agent with an IC50 of 260 μM for the inhibition of HepG2. Medroxyprogesterone Acetate EP Impurity G is a manufactured hormone of the progestin type.
599179-03-0	Vicriviroc maleate Vicriviroc maleate is a CCR5 antagonist.
60857-08-1	Prostratin Prostratin is an activator of protein kinase C (PKC) and also an activator of nuclear factor KB (NF-KB) mediated through activation of the IKKs (IKB kinases). It is an unusual non-tumorigenic phorbol ester and is found in the bark of the mamala tree of Samoa, Homalanthus nutans (Euphorbiaceae). It has potential to be useful in the treatment of HIV as it could flush viral reservoirs in latently infected CD4+ T-cells. It exhibits promising therapeutic potential against other diseases such as cancer and Alzheimer's disease. It inhibits growth and induces differentiation of AML cell lines. It inhibits tumorigenesis in KRAS mutant pancreatic cancer cells and reduces tumor growth in mouse pancreatic tumor models.
61413-54-5	Rolipram Rolipram is a selective PDE4 inhibitor that modulates cyclic AMP (cAMP) degradation. Study showed that rolipram induced neuronal differentiation of human bone marrow-mesenchymal stem cells (hBM-MSCs). It can be used as an anti-inflammatory agent.
614-60-8	trans-2-Hydroxycinnamic acid 2-Hydroxycinnamic acid is found in the herbs of Angraecum fragrans, it has photooxidant activity.
6152-57-4	3-O-Methylviridicatin O-Methylviridicatin is a metabolite produced by several species of Penicillium. It blocks TNF-alpha activation of the HIV LTR in the Hela-based system, with an IC50 of 5 mM, and inhibits virus production in the OM-10.1 cell line, a model of chronic infection responsive to induction by TNF-alpha, with an IC50 of 2.5 mM.
619331-12-3	BMS-585248 BMS585248 is a highly potent and novel human immunodeficiency virus type 1 (HIV-1) attachment inhibitor with 4-fluoro-6-azaindole core heterocycles. It targets the viral envelope protein gp120. It showed much improved in vitro potency and pharmacokinetic properties than the previous clinical candidate BMS488043.
624-49-7	Dimethyl fumarate Dimethyl fumarate is a Nrf2 activator used to treat adults with relapsing forms of multiple sclerosis.
634600-55-8	(Rac)-Saphenamycin It is a phenazine antibiotic produced by the strain of Str. canarius MG 314-hF8. It has strong effect against gram-positive bacteria and mycobacterium. It inhibits mouse leukemia L5178Y and L1210 cells with ID50 (μg/mL) of 0.15 and 0.6-2.5, respectively (in vitro determination).
634907-30-5	Censavudine Censavudine is a nucleoside reverse transcriptase inhibitor. It is active against HIV resistant to both abacavir and tenofovir. It is a candidate for people with multi-drug resistant (MDR) strains of the virus. It is a derivative of stavudine (d4T), but is less toxic. It has demonstrated potent in vitro activity against HIV-2. It was developed by Bristol Myers-Squibb and in clinic phase 2 trials.

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