Human immunodeficiency Virus (HIV)

CAS No.	Product Name	Inquiry
63585-09-1	Foscarnet sodium Foscarnet Sodium inhibits viral RNA polymerases, reverse transcriptases and DNA polymerases by non-competitive inhibition of dNTPs. It is an antiviral agent used in the treatment of cytomegalovirus retinitis. It has activity against human herpesviruses and HIV.
64009-84-3	IMB-301 IMB-301 is a specific HIV-1 replication inhibitor that binds to hA3G (human APOBEC3G, a restriction factor that inhibits human immunodeficiency 1 virus (HIV-1) replication), blocks hA3G-Vif interaction and inhibits Vif-mediated hA3G degradation. It inhibits HIV-1 replication in H9 cells with an IC50 of 8.63 uM.
64224-21-1	Oltipraz Oltipraz, a promising cancer chemopreventive agent, is a bifunctional inducer, modulating both phase I and II drug-metabolizing enzymes to enhance carcinogen detoxification.
64917-82-4	Schisantherin D Schisantherin D is isolated from the rattan of Schisandra sphenanthera. Schisantherin D shows good anti-HIV activity with the EC50 value of 0.5 micrograms/mL, and the therapeutic index (TI) value of 110.
6493-05-6	Pentoxifylline Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity. It improves red blood cell deformability, reduces blood viscosity and decreases the potential for platelet aggregation and thrombus formation. It also reduces AST and ALT levels and may improve liver histological scores in patients with NALFD/NASH, but did not appear to affect cytokines.
64936-82-9	Glycolithocholic acid 3-sulfate disodium
65358-15-8	Pseudothymidine Pseudothymidine is a C-nucleoside analog of thymidine.
66004-77-1	ddCTP ddCTP is an inhibitor of reverse transcriptases from retroviruses, such as HIV-1 and visna (Kis = 20 and 37 nM, respectively). ddCTP is commonly used to terminate chain extension produced by the Taq polymerase for its competitive effect with dCTP in cells.
66568-97-6	Tsugafolin Tsugafolin isolated from the barks of Cephalotaxus sinensis.
6736-58-9	3-Deazaadenosine 3-Deazaadenosine (3-DZA) is an inhibitor of SAH hydrolase (Ki = 3.9 μM). 3-Deazaadenosine is a modified form of the nucleoside adenosine, where a nitrogen atom in the purine ring is replaced with a carbon atom. This modification results in the compound lacking the ability to form hydrogen bonds with complementary nucleotides, making it useful in studying the role of hydrogen bonding in nucleic acid structure and function. 3-Deazaadenosine has been investigated for its potential therapeutic applications, such as in the treatment of viral infections and cancer. It is also used as a biochemical tool in research to study RNA interactions and enzymatic mechanisms.
6742-12-7	Formycin A Formycin A is produced by the strain of Nocardia intriforma M4-C5. It has the activity of resistance to Salicornia, Pyricularia oryzae and Mole disease Phanerochaetehrysosporium of potato.
674782-26-4	Leronlimab
675135-69-0	CXCR4 antagonist 1 CXCR4 antagonist 1 is a potent CXCR4 antagonist with anti-HIV activity.
680188-33-4	Ibalizumab Ibalizumab is a humanized anti-CD4 monoclonal antibody approved for the treatment of HIV-1 infection. Ibalizumab blocks HIV-1 entry into CD4 cells while preserving normal immune function.
68941-95-7	5-Fluorouracil-[15N2] 5-Fluorouracil-[15N2] is the labelled analogue of 5-Fluorouracil. 5-Fluorouracil is a pyrimidine analog that inteferes DNA synthesis. It can be used as an antineoplastic agent and antimetabolite.
69176-51-8	Tigloylgomisin P Tigloylgomisin P is purified from the stems of Schisandra pubescens. Schizandrer B shows moderate to marginal cytotoxicity against A549, PC-3, KB and KBvin human cancer cell lines.
69297-51-4	Scirpusin A
69655-05-6	Didanosine (DDI) Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.
7007-96-7	Crotoniazide
701213-36-7	BMS-626529 BMS-626529 is a member of the new drug class of HIV-1 attachment inhibitors currently in development. BMS-663068 is the phosphonooxymethyl prodrug of BMS-626529, a novel small-molecule attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4(+) T cells. The activity of BMS-626529 is virus dependent, due to heterogeneity within gp120. Research result suggest that BMS-626529 should be active against the majority of HIV-1 viruses and support the continued clinical development of the compound.

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