Human immunodeficiency Virus (HIV)

CAS No.	Product Name	Inquiry
81-27-6	Sennoside A Sennoside A, a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine. Sennoside A can be used in health products. It is an HIV-1 inhibitor that is effective against HIV-1 replication.
81430-62-8	CB-0821
82-08-6	Rottlerin Rottlerin, a principal phenolic compound of the Kamala plant Mallotus philippinensis, originally reported to inhibit PKC isoforms, especially PKCδ and CAM-KIII. Recently, it has been shown to inhibit a wide range of protein kinases, and most potently to inhibit PRAK and MAPKAP-K2 (IC50 values are 1.9 and 5 μM respectively).
83199-32-0	Sp-TTPαS Sp-TTP-α-S is used for regulation of TTP-responsive receptors and determination of their stereospecificity. Compared to TTP, it is much more stable.
83314-01-6	Bryostatin 1 Bryostatin 1, a structurally unique macrolactone marine natural product, is a protein kinase C (PKC) activator that binds with high affinity (Ki = 1.35 nM). Bryostatin 1 fails to mimic many effects caused by PMA and actually blocks some PMA-induced response in a variety of cells and tissues. Animal tests have shown bryostatin 1 may alleviate brain damage after a stroke.
83-85-2	Fuscin Produced by the strain of Oidiodendron fuscum Ag 122 and Camb 111, Fuscin has resistance to gram-positive bacteria and mycobacterium (weak) activity. Fuscin is also an anti-HIV compound and antagonist of CKR-5 (CCR5).
842166-42-1	FC131 Tfa
84290-27-7	Tucaresol
84472-85-5	3′-Azido-2′,3′-dideoxyuridine Navuridine is a RNA-directed DNA polymerase inhibitor under the development of Bayer HealthCare Pharmaceuticals. But research for the teatment of HIV infections was discontinued.
84744-28-5	Calceolarioside A Calceolarioside A is a natural compound which can be isolated from Ajuga becumbens Thunb, showing potent activity against visceral leishmaniasis.
848354-66-5	PTACH PTACH is a SAHA-based novel inhibitor of histone deacetylase (HDAC). It exerts potent growth inhibition against various human cancer cells, with EC50 values ranging from 1.1 to 9.1 μM. It shows strong activity in cancer cell growth inhibition assay. It inhibits various cancer cells with EC50 of 2.3, 9.1, 3.0, 2.6, 1.1, 4.5, 2.4, 5.0, and 4.5 μM for MDA-MB-231 breast cancer, SNB-78 central nervous system, HCT116 colon cancer, NCI-H226 lung cancer. It could inhibit the cell growth of a variety of lymphoid malignant cells through apoptosis induction, more effectively than SAHA. It upregulated anti-oxidant molecules including peroxiredoxin 1 and 2 and glutathione S-transferase at the protein level. It exhibits cytotoxicity by sustaining ROS at the higher level greater than SAHA.
849234-64-6	4-acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamide 4-acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamide is a selective HDAC1/2 inhibitor, exhibiting selectivity over class II HDACs 3-8. It shows high-affinity to HDAC1 and HDAC2 with Ki of 0.2 and 1.5 nM, respectively.
849753-15-7	PF-232798 PF-232798 is a second-generation oral CCR5 antagonist. It has broad-spectrum anti-HIV-1 activity.
850715-59-2	SAMT-247
851305-26-5	LJ001
857050-63-6	Patentiflorin-A Patentiflorin A is a potent, broadspectrum HIV-1 inhibitor. Patentiflorin A also inhibits HIV drug-resistant strains.
863434-13-3	GSK-364735
864677-55-4	IT1t IT1t is a selective CXCR4 antagonist with IC50 value of 1.1 nM in calcium mobilization assays.It may be potential useful as anti-HIV agent.
864953-39-9	BMS-663068 Tris BMS-663068 tris is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection.
86583-19-9	3-Deazaadenosine hydrochloride It is an S-adenosine homocysteine hydrolase inhibitor. It has anti-inflammatory effects, inhibiting leukocyte adhesion and chemotaxis, lymphocyt-mediated cytolysis, phagocytosis, degranulation and NF-κB signal transduction.

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