Human immunodeficiency Virus (HIV)

CAS No.	Product Name	Inquiry
64224-21-1	Oltipraz Oltipraz, a promising cancer chemopreventive agent, is a bifunctional inducer, modulating both phase I and II drug-metabolizing enzymes to enhance carcinogen detoxification.
64917-82-4	Schisantherin D Schisantherin D is isolated from the rattan of Schisandra sphenanthera. Schisantherin D shows good anti-HIV activity with the EC50 value of 0.5 micrograms/mL, and the therapeutic index (TI) value of 110.
6493-05-6	Pentoxifylline Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity. It improves red blood cell deformability, reduces blood viscosity and decreases the potential for platelet aggregation and thrombus formation. It also reduces AST and ALT levels and may improve liver histological scores in patients with NALFD/NASH, but did not appear to affect cytokines.
65358-15-8	Pseudothymidine Pseudothymidine is a C-nucleoside analog of thymidine.
66004-77-1	ddCTP ddCTP is an inhibitor of reverse transcriptases from retroviruses, such as HIV-1 and visna (Kis = 20 and 37 nM, respectively). ddCTP is commonly used to terminate chain extension produced by the Taq polymerase for its competitive effect with dCTP in cells.
6736-58-9	3-Deazaadenosine 3-Deazaadenosine (3-DZA) is an inhibitor of SAH hydrolase (Ki = 3.9 μM).
6742-12-7	Formycin A Formycin A is produced by the strain of Nocardia intriforma M4-C5. It has the activity of resistance to Salicornia, Pyricularia oryzae and Mole disease Phanerochaetehrysosporium of potato.
675135-69-0	CXCR4 antagonist 1 CXCR4 antagonist 1 is a potent CXCR4 antagonist with anti-HIV activity.
68941-95-7	5-Fluorouracil-[15N2] 5-Fluorouracil-[15N2] is the labelled analogue of 5-Fluorouracil. 5-Fluorouracil is a pyrimidine analog that inteferes DNA synthesis. It can be used as an antineoplastic agent and antimetabolite.
69176-51-8	Tigloylgomisin P Tigloylgomisin P is purified from the stems of Schisandra pubescens. Schizandrer B shows moderate to marginal cytotoxicity against A549, PC-3, KB and KBvin human cancer cell lines.
69655-05-6	Didanosine (DDI) Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.
701213-36-7	BMS-626529 BMS-626529 is a member of the new drug class of HIV-1 attachment inhibitors currently in development. BMS-663068 is the phosphonooxymethyl prodrug of BMS-626529, a novel small-molecule attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4(+) T cells. The activity of BMS-626529 is virus dependent, due to heterogeneity within gp120. Research result suggest that BMS-626529 should be active against the majority of HIV-1 viruses and support the continued clinical development of the compound.
70288-86-7	Ivermectin Ivermectin is a glutamate-gated chloride channel (GluCls) activator, which is used as an antiparasitic drug for the treatment of certain parasitic roundworm infections. Ivermectin inhibits the chloride channels of helminthic parasites and has been shown to have clinical efficacy for the treatment of onchocerciasis, strongyloidiasis, and ectoparasitic infection. Ivermectin is a mixture of mostly Ivermectin B1a (>80%) with some Ivermectin B1b (<20%), which are macrolides from Streptomyces avermitilis.
7057-48-9	beta-L-D4A beta-L-D4A is a nucleoside HIV-1 reverse transcriptase inhibitor.
7081-36-5	Leptomycin-A Leptomycin A, a Streptomyces metabolite, is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A suppresses HIV-1 replication. Less potent than Leptomycin B.
70831-56-0	L-Chicoric acid Cichoric acid, that can be isolated from the herbs of Echinacea purpurea, has been shown to inhibit hyaluronidase and HIV-1 integrase, and to possess phagoeytosis stimulatory activity in vitro and in vivo and antiviral acitivy. Chicoric acid may reduce acute alcohol-induced steatosis in mice through interfering with the induction of iNOS and iNOS-dependent signaling cascades in the liver. Chicoric acid also inhibited cell viability and induced apoptosis in 3T3-L1 preadipocytes which was characterized by chromatin condensation and poly ADP-ribose-polymerase (PARP) cleavage.
716354-86-8	CCR5 antagonist 1 CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2 that can inhibit HIV replication.
71678-03-0	Ilimaquinone Ilimaquinone is a marine sponge metabolite with antimicrobial, anti-HIV, anti-mitotic, and anti-inflammatory properties. Ilimaquinone significantly enhanced TRAIL-induced apoptosis in HCT 116 cells and sensitized colon cancer cells to TRAIL-induced apoptosis through increased caspase-8, -3 activation, PARP cleavage, and DNA damage. Ilimaquinone also reduced the cell survival proteins Bcl2 and Bcl-xL, while strongly up-regulating death receptor (DR) 4 and DR5 expression.
72029-21-1	ddATP-trisodium ddATP (2',3'-Dideoxyadenosine 5'-triphosphate) trisodium, an active metabolite of 2',3'-dideoxyinosine, is a chain-elongating inhibitor of DNA polymerase. ddATP trisodium can be used for Sanger method for DNA sequencing and research of virus infection.
729607-74-3	BMS-707035 BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM.

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