Human immunodeficiency Virus (HIV)

CAS No.	Product Name	Inquiry
181785-84-2	Elvucitabine
1818867-24-1	Fipravirimat Fipravirimat is a potent HIV-1 inhibitor. Fipravirimat has the potential for HIV and AIDS research.
1818868-23-3	(1S)-4-[(1R,3aR,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-[2-(1-hydroxy-4-methylsulfonylcyclohexyl)ethylamino]-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]-1-(fluoromethyl)cyclohex-3-ene-1-carboxylic acid
1821309-39-0	HIV-1-inhibitor-6 HIV-1 inhibitor-6 (compound 9), a diheteroarylamide-based compound, is a potent HIV-1 pre-mRNA alternative splicing inhibitor. HIV-1 inhibitor-6 blocks HIV replication. HIV-1 inhibitor-6 is active against wild-type HIV-1IIIB (subtype B, X4-tropic) and HIV-1 97USSN54 (subtype A, R5-tropic) with EC50s of 0.6 μM and 0.9 μM, respectively. HIV-1 inhibitor-6 inhibits HIV strains resistant to drugs targeting HIV reverse transcriptase, protease, integrase, and coreceptor CCR5 with EC50s ranging from 0.9 to 1.5 μM.
182316-44-5	Cyclotriazadisulfonamide Cyclotriazadisulfonamide is a CD4-targeted HIV entry inhibitor. CADA inhibits HIV at submicromolar levels by specifically down-modulating cell-surface and intracellular CD4.
183904-53-2	(+)-Dihydrocalanolide A
184539-13-7	Teicoplanin sodium
185220-03-5	6-Chloro-2-(1-furo[2,3-c]pyridin-5-yl-ethylsulfanyl)-pyrimidin-4-ylamine
1854111-80-0	PB(OH)3
1854126-41-2	Chloroquine-[d5] Chloroquine-[d5], is the labelled analogue of Chloroquine. Chloroquine is an antimalarial agent.
1854126-42-3	Chloroquine-[d5] Diphosphate Chloroquine-[d5] Diphosphate, is the labelled analogue of Chloroquine Diphosphate. Chloroquine phosphate is an antimalarial drug and weak intercalating agent. It inhibits TLR signalling in plasmacytoid dendritic cells (pDCs). It has been used in emergency of COVID-19.
185897-02-3	Indinavir-[d6] Indinavir-[d6] is the labelled analogue of Indinavir, which is a member of the novel hydroxyaminopentane amide class of HIV-1 protease inhibitors. It is used as an antiviral.
1859189-55-1	BNM-III-170 BNM-III-170 can inhibit HIV-1 virus entry into target cells.
185991-07-5	AMD3465 hexahydrobromide AMD 3465 is a potent and selective antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells. AMD 3465 (50 nM) totally blocks CXCL12-induced calcium mobilization, with an IC50 of 17 nM, but shows no effect on the intracellular calcium fluxes elicited by the CCR5 ligands RANTES, LD78β and MIP-1β in U87.CD4.CCR5 cells. MD3465 was even 10-fold more effective as a CXCR4 antagonist, while showing no interaction whatsoever with CCR5. AMD3465 has the potential to mobilize hematopoietic stem cells.
185991-24-6	AMD 3465 AMD 3465,a N-pyridinylmethylene monocyclam, is a selective antagonist of CXCL12/CXCR4-mediated interactions including ligand binding and receptor activation. With its enhanced potency against the CXCR4 receptor compared with plerixafor, AMD 3465 has been
186452-09-5	(S)-3-(Pyridine-3-yl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate GPI-1046 is a immunophilin ligand without antibiotic action and attenuates ethanol intake in part through the upregulation of glutamate transporter 1 (GLT1) in PFC and NAc-core. GPI-1046 is an analog of FK506, which is an immunophilin ligand that has been shown neuroprotective effects in neurodegenerative disease models. GPI-1046 readily crosses the blood-brain barrier and promotes the regeneration of dopamine (DA) cells in the CNS in association with functional recovery in rodent models. GPI-1046 improves HIV-associated injury of peripheral nerves.
186694-02-0	Fasudil-hydrochloride-semihydrate Fasudil (HA-1077; AT877) hydrochloride semihydrate is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil hydrochloride semihydrate is also a potent Ca2+ channel antagonist and vasodilator.
188062-50-2	Abacavir Sulfate (2:1) Abacavir is a commonly used nucleoside analogue with potent antiviral activity against HIV-1. Abacavir is an analog of guanosine (a purine). Its target is the viral reverse transcriptase enzyme.
19022-51-6	Ophiobolin C A member of the ophiobolin class of phytotoxic metabolites produced by many species of the genus bipolaris; inhibits human CCR5 binding to the envelope protein gp120 and CD4 that mediates HIV-1 entry into cells.
1919828-81-1	DDX3-IN-2 DDX3-IN-2 is an active DEADbox polypeptide 3 (DDX3) inhibitor (IC50 = 0.3 μM) with broad spectrum antiviral activity and the potential to overcome HIV resistance.

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