Human immunodeficiency Virus (HIV)

all Activators (8) Antagonists (4) Inducer (1) Inhibitors (721)

CAS No.	Product Name	Inquiry
221662-50-6	L-2'-Fd4C
2219362-41-9	GS-9822 GS-9822 is one of novel non-catalytic site integrase inhibitors (NCINIs), which is a potential class of antiretroviral (ARV) agents. GS-9822 exhibits a potent effect against the T174I mutant (EC50: 3.0 ± 0.9 nM) and IN polymorphic variants (fold shift: 0.4 to 1.3). Studies showed that it has excellent pharmacokinetic properties and metabolic stability.
2234273-72-2	NBD-14189 NBD-14189 is a potent HIV-1 entry antagonist with an IC50 of 89 nM against the HIV 1HXB2 pseudovirus. NBD-14189 binds to HIV-1 gp120 and shows potent antiviral activity (EC50<200 nM).
223769-59-3	HIV-Protease-Substrate-1 HIV Protease Substrate 1, a fiuorogenic HIV protease substrate, can be used to study enzymatic activity of HIV protease.
2245231-10-9	Pirmitegravir Pirmitegravir is a potent and first-in-class allosteric integrase (ALLINI) inhibitor that targets LEDGF/p75 binding site, and has excellent antiviral and safety properties. It shows picomolar IC50 in human PBMCs with a therapeutic index of >24000 for HIV-1.
2249755-49-3	A3N19 A3N19 is a potent HIV-1 non-nucleoside reverse transcriptase inhibitor, with an EC50 of 3.28 nM against HIV-1 IIIB.
2249814-82-0	Dolutegravir-d5 Dolutegravir-d5 is deuterium labeled Dolutegravir. Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM).
2253744-59-9	KRH-3955 hydrochloride KRH-3955 hydrochloride is an orally bioavailable CXCR4 antagonist, and a highly potent and selective inhibitor of X4 HIV-1, with an EC50 of 0.3-1.0 nM. It inhibits the binding of CXCR4 to SDF-1α with an IC50 of 0.61 nM.
226700-79-4	Fosamprenavir Fosamprenavir, also called as GW433908, Lexiva and Telzir, is an oral prodrug of the protease inhibitor (PI) amprenavir. Combined with other antiretroviral agents, Fosamprenavir is indicated for the treatment of patients with HIV infection, particularly those who have not previously received antiretroviral therapy.
226700-81-8	Fosamprenavir Calcium Salt HIV protease inhibitor; water soluble prodrug of amprenavir.
229005-80-5	TAK-779 TAK-779 is a potent, dual antagonist at chemokine receptors CCR2 and CCR5 with IC50 = 1.4 nM at CCR5 and 2.3 nM at CCR2. Antagonists of both CCR2 and CCR5 such as TAK-779 have been investigated for treatment of viruses, rheumatoid arthritis, multiple sclerosis, and cancer. CCR5 is particularly targeted for anti-HIV therapy, since HIV entry into cells requires chemokine coreceptors CCR5 and CXCR4.
229975-97-7	Atazanavir Sulfate Atazanavir is a HIV protease inhibitor with Ki of 2.66 nM. It is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus.
2302046-54-2	HIV-1-inhibitor-27 HIV-1 inhibitor-27 (compound 5) is a potent HIV-1 inhibitor with IC50s of 16 μM, 0.5 μM and 0.39 μM for HIV-1 YU2, NL4-3 and 89.6 strain, respectively. HIV-1 inhibitor-27 has low cytotoxicity with a CC50 of 128 μM in TZM-bl cells. HIV-1 inhibitor-27 can be used for researching AIDS.
2305092-66-2	F9170
2309699-17-8	Mavorixafor trihydrochloride Mavorixafor trihydrochloride is a potent, selective and orally available CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. It also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with IC50s of 1 and 9 nM, respectively.
231957-54-3	MIV-150 MIV-150 is an allosteric inhibitor of HIV-1 and HIV-2 reverse transcriptase with both EC50 values of 1 nM in vitro.
2319747-14-1	LDC4297 hydrochloride LDC4297 is a potent and selective cyclin-dependent protein kinase 7 (CDK7) inhibitor with an IC50 of 0.13 nM.
2319-84-8	α-Lipoic Acid sodium
23214-92-8	Daunorubicin EP Impurity D (Doxorubicin) Doxorubicin is an anthracycline antibiotic produced in Str. peucetius var. caesinus. Doxorubicin has anti-Gram-positive bacteria activity and has a broad anti-tumor spectrum. Doxorubicin is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.
233271-65-3	HI-236

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