Human immunodeficiency Virus (HIV)

all Activators (8) Antagonists (4) Inducer (1) Inhibitors (721)

CAS No.	Product Name	Inquiry
2450-53-5	Isochlorogenic acid A 3,5-Di-O-caffeoylquinic acid isolated from the flowerbud of Lonicera japonica Thunb. It has hepatoprotective and potent anti-hepatitis B activities.
2457357-99-0	FNC-TP FNC-TP is the intracellular active form of FNC which is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV.
2459929-46-3	HIV-1-inhibitor-42 HIV-1 inhibitor-42 (compound 5b) is a potent HIV-1 inhibitor, with an IC50 of 0.06 μM. HIV-1 inhibitor-42 inhibits HIV-1 RT RNA-dependent DNA polymerase and DNA-dependent DNA polymerase, with IC50 values of 0.518 and 0.072 .
2459929-62-3	HIV-IN-5 HIV-IN-5 is an investigational small molecule with potent inhibitory activity against HIV-1, demonstrating an IC50 of 0.16 μM. It targets key components of the HIV lifecycle, such as reverse transcriptase, integrase, or protease, and effectively inhibits HIV DNA-dependent DNA polymerization with an IC50 of 2.18 μM. By binding to the NNRTI binding pocket (NNIBP) on the reverse transcriptase enzyme, HIV-IN-5 disrupts viral replication, reduces viral load, and slows disease progression, making it a promising candidate for inclusion in antiretroviral therapies for managing and treating HIV/AIDS.
2475658-74-1	HIV-1-inhibitor-25 HIV-1 inhibitor-25 (compound R-12a) is a highly potent HIV-1 reverse transcriptase, with an IC50 value of 0.1061 μM. HIV-1 inhibitor-25 has high antiretroviral activity against WT HIV-1 with an EC50 of 13.6 nM, and exhibits relatively low cytotoxicity with a CC50 of 33.13 μM in MT-4 cells. HIV-1 inhibitor-25 also has inhibitory activity against HIV-1 mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L+V106A) with EC50 of 0.1961 ~ 5.8136 μM. HIV-1 inhibitor-25 can be used for researching AIDS.
2475658-75-2	HIV-1-inhibitor-24 HIV-1 inhibitor-24 (compound S-12a) is a highly potent HIV-1 reverse transcriptase, with an IC50 value of 9.5 nM. HIV-1 inhibitor-24 has high antiretroviral activity against WT HIV-1 with an EC50 of 1.6 nM, and exhibits relatively low cytotoxicity with a CC50 of 9.07 μM in MT-4 cells. HIV-1 inhibitor-24 is well tolerated at a dose of 2 g/kg in mice and has a significant cardiovascular safety.
2484771-19-7	HF50731 HF50731 (compound 21) is a potent CXCR4 antagonist. HF50731 shows strong CXCR4 binding affinity, with IC50 of 19.8 nM.
2493426-43-8	HIV-1-inhibitor-43 HIV-1 inhibitor-43 is a potent HIV-1 inhibitor with an EC50 of 21.3 nM, 6.2 nM, < 0.7 nM and < 0.7 nM for Y188L, K103N-Y181C, K103N and Y181C, respectively. HIV-1 inhibitor-43 can reduce HIV-1 RNA and protein p24 expression.
2499537-22-1	Denv-IN-7
2505-56-8	(±)-Corydine (±)-Corydine is a racemic mixture of corydine, containing both the (+) and (−) enantiomers. It is studied for its potential analgesic, anti-inflammatory, and neuroprotective effects. Research focuses on understanding its overall biological impact and the contributions of each enantiomer to its therapeutic potential.
252642-12-9	Apelin-36 (human) Apelin-36 (human) is an endogenous ligand of the G protein-coupled APJ receptor with EC50 value of 20 nM that is secreted by adipocytes. It is the full-length mature peptide produced from the translated 77 amino acid prepropeptide. It acts primarily in the central nervous and peripheral system. It is important in regulating fluid homeostasis, cardiovascular function, insulin and hypertension sensitivity. It potently blocks HIV-1 and HIV-2 strains entry into cells expressing APJ and CD4 and limits HIV infection. It endogenously binds with high affinity to human APJ receptors expressed in HEK 293 cells.
2554618-33-4	HIV-1-inhibitor-22 HIV-1 inhibitor-22 (compound 11a) is a potent HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor, with an IC50 value of 3.63 μM for HIV-1 RT. HIV-1 inhibitor-22 has antiretroviral activity against HIV-1 WT and K103N strains with EC50s of 0.304 M and 0.201 μM, also has low cytotoxicity (CC50 > 227 μM).
2554620-04-9	HIV-1-inhibitor-21 HIV-1 inhibitor-21 (compound 9b) is a potent HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor, with an IC50 value of 0.55 μM for HIV-1 RT. HIV-1 inhibitor-21 has antiretroviral activity against HIV-1 WT and K103N strains with EC50s of 12.7 nM and 10.4 nM, and has relatively low cytotoxicity (MT-4 cells CC50 =10.2 μM).
2554622-28-3	HIV-1-inhibitor-23 HIV-1 inhibitor-23 (compound 12a) is a highly potent HIV-1 non-nucleoside reverse transcriptase inhibitor, with EC50s of 24.9 nM and 10.4 nM for HIV-1 WT and HIV-1 K103N, respectively. HIV-1 inhibitor-23 has low cytotoxicity (CC50 > 221 μM) and a favorable in vitro microsomal stability.
2560576-15-8	PYR01
2563866-80-6	Indinavir-sulfate-ethanolate Indinavir sulfate ethanolate (MK-639 ethanolate) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir sulfate ethanolate exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing Apoptosis. Indinavir sulfate ethanolate is also a SARS-CoV 3CLpro inhibito.
2567770-65-2	Influenza antiviral conjugate-1
257891-65-9	HIV-1 inhibitor-69
2586-60-9	Chlorazol Violet N Direct Violet 1, an azo dye, is a textile dye. Direct Violet 1 is also the protein-protein interaction (PPI) between the SARS-CoV-2 spike protein and ACE2 inhibitor with IC50s of 1.47-2.63 µM.
2611373-74-9	Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium shows substantially longer t1/2 values than tenofovir in human liver microsomes, and has strong anti-HIV activity in vitro and enhances pharmacokinetic properties in vivo.

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