HIV Protease

CAS No.	Product Name	Inquiry
226700-81-8	Fosamprenavir Calcium Salt HIV protease inhibitor; water soluble prodrug of amprenavir.
2306328-43-6	GS-9770
2563866-80-6	Indinavir-sulfate-ethanolate Indinavir sulfate ethanolate (MK-639 ethanolate) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir sulfate ethanolate exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing Apoptosis. Indinavir sulfate ethanolate is also a SARS-CoV 3CLpro inhibito.
26543-89-5	Hinokinin Hinokinin is a lignan isolated from the stems of Hypoestes aristate. Hinokinin has been identified as a potential antichagasic agent.
2738376-78-6	Amprenavir-d4-1 Amprenavir-d4-1 is deuterium labeled Amprenavir. Amprenavir (VX-478) is a HIV protease inhibitor (Ki=0.6 nM) used to treat HIV infection. Amprenavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.09 μM.
2883496-10-2	HIV-1 inhibitor-53
2892016-32-7	HIV-1 protease-IN-6
2916441-36-4	HIV-1 protease-IN-7
2925287-54-1	HIV-1 protease-IN-11
2925287-55-2	HIV-1 protease-IN-8
2925287-59-6	HIV-1 protease-IN-12
2925381-27-5	HIV-1 protease-IN-9
313682-08-5	Brecanavir Brecanavir is a tyrosyl-based arylsulfonamide, high-affinity, protease inhibitor (PI) for the treatment of human immunodeficiency virus type-1. This compound potently inhibited HIV-1 in cell culture assays with 50% effective concentrations (EC(50)s) of 0.2 to 0.53 nM and was equally active against HIV strains utilizing either the CXCR4 or CCR5 coreceptor, as was found with other PIs. Brecanavir had a <5-fold increase in EC(50)s against 80% of patient isolates tested and had a greater mean in vitro potency than amprenavir, indinavir, lopinavir, atazanavir, tipranavir, and darunavir.
332131-32-5	RK-682 hemicalcium It is a dimeric calcium complex of the major analogue of tetronic acid complex isolated from streptomyces. It inhibits protein tyrosine phosphatases, phospoholipase A2, heparinase and HIV-1 protease.
77174-33-5	Acetyl-binankadsurin A Acetyl-binankadsurin A is a lignan isolated from Kadsura longipedunculata. Acetyl-binankadsurin A remarkably downregulated the expression of CCR1, p-NF-κBp65, p-IκBα, p-STAT1 and TNF-α proteins, which were upregulated in CCl4-induced hepatic fibrosis and LPS-THP-1 cells.
78860-37-4	Hinnuliquinone
81907-61-1	Ganoderic acid B Ganoderic acid B (GAB) possesses various pharmaceutical effects and has been used as a chemical marker in quality control of G. lucidum and related products
886441-72-1	Longipedunin A Longipedunin A is a lignan isolated from Kadsura longipedunculata. Longipedunin A acts as an HIV-1 Protease inhibitor.
93939-77-6	ddCTP trilithium
159989-65-8	Nelfinavir Mesylate Nelfinaviris a potent and orally bioavailable human immunodeficiency virus HIV-1 protease inhibitor.

Acquired immunodeficiency syndrome is a chronic disease characterized by multiple life-threatening illnesses caused by a retro-virus, human immunodeficiency virus (HIV). A key therapeutic strategy for HIV infection is highly active antiretroviral therapy (HAART), which is a customized combination of anti-retroviral drugs designed to combat the HIV infection. Among various HAART treatment options, small molecule drugs with HIV protease as a drug target have been found to be effective in the treatment of HIV infection/AIDS.

HIV protease, a homodimeric aspartate protease that is critical to the life cycle of the virus, cleaves newly synthesized polyproteins to produce the mature protein components of an infectious HIV virion. Therefore, HIV protease is a key drug target in designing anti-retroviral drugs for the treatment of HIV/AIDS (acquired immunodeficiency syndrome).

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