Hepatitis C Virus (HCV)

CAS No.	Product Name	Inquiry
1312547-19-5	Samatasvir Samatasvir is a potent HCV replication NS5A inhibitor that is effective and selective against infectious HCV and replicons with EC50s falling within a tight range of 2 to 24 pM for genotype 1-5 replicons.
1312608-46-0	Coblopasvir
1314795-11-3	Radalbuvir Radalbuvir is a Hepatitis C virus NS 5 protein inhibitor for the treatment of hepatitis C virus (HCV) infection developed by Gilead Sciences. In 2014, Gilead completed a phase II trial for Hepatitis C in USA.
131707-25-0	Umifenovir Arbidol is an antiviral agent using for the treatment of influenza infection in Russia and China. It inhibits membrane fusion and prevents contact between the virus and target host cells. Fusion between the viral capsid and the cell membrane of the target cell is inhibited and this prevents viral entry to the target cell. Although some Russian studies have shown it to be effective, it is not approved for use in Western countries.
1331942-30-3	GSK5852 GSK5852 (GSK2485852) is an HCV NS5B polymerase inhibitor, with an IC50 value of 50 nM. GSK5852 displays antiviral activity and inhibits HCV with EC50s of 3.0 nM (genotype 1a, GT1a) and 1.7 nM (GT1b), respectively.
1333126-31-0	Azvudine hydrochloride Azvudine hydrochloride is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine hydrochloride inhibits NRTI-resistant viral strains.
1334314-19-0	Unii-779TT17O5A
1334513-10-8	Sofosbuvir impurity J Sofosbuvir impurity J is a diastereoisomer and impurity of Sofosbuvir, an inhibitor of HCV RNA replication with strong anti-hepatitis C virus activity.
1337482-17-3	Sofosbuvir 3',5'-Bis-(S)-phosphate Sofosbuvir 3',5'-Bis-(S)-phosphate, an impurity of PSI-7977, which is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
1346601-82-8	Deferiprone-[d3] Deferiprone-[d3] is a labelled product of Deferiprone, which is an iron chelator.
1350462-55-3	MK-5172 hydrate In biochemical assays, MK-5172 was effective against a panel of major genotypes and variants engineered with common resistant mutations observed in clinical studies with other NS3/4a protease inhibitors. In the replicon assay, MK-5172 demonstrated subnanomolar to low-nanomolar EC50s against genotypes 1a, 1b, and 2a. In rats, MK-5172 showed a plasma clearance of 28 ml/min/kg and plasma half-life of 1.4 hr. When dosed p.o. at 5 mg/kg, the plasma exposure of MK-5172 was good with an AUC of 0.7 uM.hr. The liver exposure of the compound was quite good (23 uM at 4 hr), and MK-5172 remained in liver 24 hr after a single p.o. 5 mg/kg dose. At 24 hr, the liver concentration of MK-5172 was 0.2 uM, which was over 25-fold higher than the IC50 in the replicon assay with 50% NHS. When dosed to dogs, MK-5172 showed low clearance of 5 ml/min/kg and a 3 hr half-life after i.v. 2 mg/kg dosing and had good plasma exposure (AUC=0.4 uM.hr) after a p.o. 1 mg/kg dose.
1350735-70-4	CID 58059494
1355050-21-3	GS-443902 trisodium GS-443902 trisodium is a potent inhibitor of viral RNA-dependent RNA-polymerases (RdRp), with IC50s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively.
1355149-45-9	GS-443902 GS-443902 is a potent inhibitor of viral RNA-dependent RNA-polymerases (RdRp), with IC50s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively.
1365970-03-1	glecaprevir Glecaprevir is a suppressive agent of hepatitis C virus (HCV). Glecaprevir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 4.09 μM.
1379746-42-5	Astodrimer
1394157-34-6	Sofosbuvir impurity N Sofosbuvir impurity N is a diastereoisomer and impurity of Sofosbuvir, an inhibitor of HCV RNA replication with strong anti-hepatitis C virus activity.
1401839-25-5	HCV-IN-3 HCV-IN-3 is an inhibitor of hepatitis C virus (HCV) NS3/4a protein, with an IC50 of 20 μM and a Kd of 29 μM.
1401924-49-9	NVP018
141117-12-6	Celgosivir hydrochloride Celgosivir hydrochloride is the hydrochloride salt of Celgosivir which is anα-glucosidase inhibitor and inhibits bovine viral diarrhoea virus (BVDV) with an IC50 of 1.27 μM in vitro assay.

※ Please kindly note that our services are for research use only.