Hepatitis C Virus (HCV)

CAS No.	Product Name	Inquiry
381731-49-3	Antiviral agent 30
39023-73-9	NHC-diphosphate N 4-Hydroxycytidine (NHC) is an antiviral ribonucleoside analog that acts as a competitive alternative substrate for virally encoded RNA-dependent RNA polymerases. NHC-diphosphate is an active phosphorylated form.
394730-60-0	Boceprevir An NS3 serine protease inhibitor of hepatitis C virus, for the treatment of HCV infection.
402957-28-2	Telaprevir Telaprevir is a potent, selective, peptidomimetic inhibitor of the hepatitis C virus (HCV) NS3-4A serine protease, and it demonstrated excellent antiviral activity both in genotype 1b HCV replicon cells (50% inhibitory concentration [IC50] = 354 nM) and in human fetal hepatocytes infected with genotype 1a HCV-positive patient sera (IC50 = 280 nM). Telaprevir forms a covalent but reversible complex with the genotype 1a HCV NS3-4A protease in a slow-on, slow-off process with a steady-state inhibition constant (K(i)*) of 7 nM. Dissociation of the covalent enzyme-inhibitor complex of Telaprevir and genotype 1a HCV protease has a half-life of almost an hour. A >4-log10 reduction in the HCV RNA levels was observed after a 2-week incubation of replicon cells with Telaprevir, with no rebound of viral RNA observed after withdrawal of the inhibitor. In several animal species, Telaprevir exhibits a favorable pharmacokinetic profile with high exposure in the liver. In a recently developed HCV protease mouse model, Telaprevir showed excellent inhibition of HCV NS3-4A protease activity in the liver.
40372-00-7	Viramidine Hydrochloride Taribavirin hydrochloride is an orally active inosine monophosphate dehydrogenase inhibitor, has activity against a wide range of viruses, especially the hepatitis C virus and influenza virus. Taribavirin hydrochloride is a Ribavirin prodrug, is designed to concentrate within the liver to target HCV-infected hepatocytes while minimizing distribution within red blood cells (RBCs) and the development of hemolytic anemia.
442-52-4	Clemizole Clemizole is an H1 antagonist acts as a TRPC5 channel blocker (IC50 values are 1.1, 6.4, 9.1, 11.3 and 26.5 μM for TRPC5, TRPC4, TRPC3, TRPC6 and TRPC7 respectively).
442666-98-0	Anguizole Anguizole is a small molecule inhibitor of HCV replication and alters NS4B's subcellular distribution.
478182-28-4	R-1479 R1479 is a potent and highly specific inhibitor of HCV replication in cell culture, and that its triphosphate is a potent and highly selective inhibitor of NS5B mediated RNA synthesis, the HCV encoded RNA polymerase.
494856-61-0	BILB 1941
501081-38-5	FGI-106 FGI-106, a potent and broad-spectrum inhibitor, has inhibitory activity against a variety of viruses with EC50s of 100, 800 and 400-900 nM against Ebola, Rift Valley and Dengue Fever viruses, respectively. It also inhibits non-hemorrhagic fever viruses HCV and HIV-1 with EC50s of 200 and 150 nM, respectively.
50886-61-8	Isoeuphorbetin Isoeuphorbetin is a dimeric coumarin isolated from Viola philippica. Isoeuphorbetin is a potent inhibitor of HCV protease with an IC50 of 3.63 µg/mL.
50924-49-7	Mizoribine Bredinin is a nucleoside antibiotic produced by Eupenicillum brefeldianum M-2166. It has anti-L-5178Y cell and anti-pox virus activity, not against bacteria and fungi,
517-44-2	SENNIDINE B Purgative activity.
548-61-8	Tris(4-aminophenyl)methane Tris(4-aminophenyl)methane is a weak hepatitis C virus (HCV) helicase inhibitor and a triphenylmethane dye.
55396-45-7	Pseudane IX 2-Nonylquinolin-4(1H)-one is a quinolone alkaloid found in P. aeruginosa with a variety of biological activities. It reduces infection of Huh 7.5 cells by the hepatitis C virus (HCV) with an IC50 value of 1.4 µg/ml.
581772-30-7	2',5-Difluoro-2'-deoxycytidine 2',5-Difluoro-2'-deoxycytidine has potent activity against HCV and toxicity to ribosomal RNA (rRNA).
593960-11-3	PIK-93 PIK-93 is a potent PI3K inhibitor.
610753-87-2	KIN101 KIN101 is a potent RNA viral inhibitor with IC50s of 2 μM, >5 μM for influenza virus and Dengue virus (DNV), respectively.
632325-71-4	Filociclovir Filociclovir is a broad-spectrum anti-herpesvirus compound with good antiviral activity against cytomegalovirus (CMV), herpes simplex virus (HHV)-6 and HHV-8, with EC50 values ranging from 0.7 μM to 8 μM.
640281-90-9	Valopicitabine Valopicitabine is a nucleoside analogue and the orally bioavailable 2'-C-methylcytidine (NM107) prodrug, with anti-hepatitis C virus (HCV) activity.

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