Hepatitis C Virus (HCV)

CAS No.	Product Name	Inquiry
1350514-68-9	MK-5172 Grazoprevir is a hepatitis C virus protease inhibitor developed for the treatment of hepatitis C. It suppresses NS3 and NS4A, which play a role in the virus splitting its polyprotein into the functional virus proteins. Grazoprevir is often used in combination with elbasvir or ribavirin.
1377049-84-7	Velpatasvir Velpatasvir is a selective Hepatitis C virus NS 5 protein inhibitor originated by Gilead Sciences. It showed pan-genotypic activity and a high barrier to resistance in HCV replicon assays.
923604-59-5	Simeprevir Simeprevir plays an important role in HCV replication. Data from phase I and II clinical trials of TMC-435350 (TMC 435350; TMC 435; TMC-435350) to date have shown that this agent is well tolerated as a once-daily oral therapy and provides potent antiviral activity in HCV genotype 1-infected subjects, with restoration of liver enzymes and no evidence of viral breakthrough.
1190307-88-0	Sofosbuvir Sofosbuvir is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled sofosbuvir as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
443642-29-3	7-Deaza-2'-C-methyladenosine 7-Deaza-2'-C-methyladenosine is a hepatitis C virus (HCV) polymerase inhibitor.
1163-36-6	Clemizole hydrochloride The hydrochloride salt form of clemizole, which is a histamine H1 antagonist with antitumor activity. It also has hepatitis C antiviral effect through restraining NS4B function and could also be used as an anticonvulsant in zebrafish Dravet syndrome model.
38101-59-6	Oglufanide Oglufanide is a VEGFR inhibitor that may suppress angiogenesis.
1190308-01-0	PSI-7976 PSI-7976 is an inhibitor of HCV RNA replication with EC50 value of 1.07μM. PSI-7851 is a phosphoramidate prodrug of PSI-7411 and has potent anti-hepatitis C virus (HCV) activity. It is a mixture of two diastereoisomers. PSI-7976 is one of them. Another one is PSI-7977. PSI-7851 is firstly activated through being hydrolyzed by CatA and CES1in the liver cells. It is found that CatA prefers PSI-7977 as a substrate over PSI-7976 while CES1 preferentially hydrolyzes PSI-7976 over PSI-7977. Since CES1 does not express in clone A replicon cells, the ability of PSI-7976 and PSI-7977 to inhibit HCV RNA replication is different in these cells. PSI-7977 is more potent than PSI-7976 with EC50 value of 92nM.
863329-66-2	(2'R)-2'-deoxy-2'-fluoro-2'-C-methyluridine PSI-6206 is a selective HCV RNA polymerase inhibitor. It is the unphosphorylated parent compound of triphosphate analog PSI-7409, which is a potent inhibitor of the HCV NS5B RNA dependent RNA polymerase.
1011529-10-4	Azvudine Azvudine is a nucleoside reverse transcriptase inhibitor (NRTI), which exhibits inhibtory effects on HIV, HBV and HCV.
63968-64-9	Artemisinin Artemisinin is a natural product originally isolated from plants of the genus Artemisia. It effectively kills malarial parasites of the genus Plasmodium. It is usually used in combination therapy for the treatment of malaria. Artemisinin is also used against a wide range of trematodes, including Schistosoma. Artemisinin is an inhibitor of human NOS2 (iNOS) with anticancer activity.
548-04-9	Hypericin It is a natural antidepressant produced by the strain of Hypericium perforatum (plant extract). It is an anti-retroviral agent and protein kinaze-C inhibitor.
1007884-60-7	Monodes(N-carboxymethyl)valine Daclatasvir Monodes(N-carboxymethyl)valine Daclatasvir is an impurity of Daclatasvir, a medication that is effective against hepatitis C virus (HCV).
524-15-2	gamma-fagarine γ-Fagarine is a natural compound extracted from Phellodendron chinense.
67884-03-1	Platycodin D3 Platycodin D3 has anti-hepatitis C virus (HCV) activity. It can be used as an expectorant in a variety of lung inflammatory diseases and regulate the production and secretion of mucin in the airway. Platycodin D3 is a triterpenoid compound and an inhibitor of NF-κB.
58316-41-9	Saikosaponin B2 Saikosaponin B1 is extracted from the herb of Bupleurum chinense DC. It acted on HCV E2. It inhibited infection by several genotypic strains and prevented binding of serum-derived HCV onto hepatoma cells.
508-02-1	Oleanolic acid Oleanolic Acid is a non-toxic, hepatoprotective triterpenoid found in Phytolacca Americana, which exerts antitumor and antiviral properties. Oleanolic Acid is a natural compound used in cosmetics material.
144875-48-9	Resiquimod Resiquimod is an imidazoquinolinamine and TLR7 agonist with antitumor and antiviral activity.

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