Hepatitis C Virus (HCV)

CAS No.	Product Name	Inquiry
1009119-64-5	Daclatasvir Daclatasvir, inhibits the HCV protein NS5A, and thus can be used as a drug candidate for the treatment of hepatitis C (HCV).
1009119-83-8	HCV-IN-29 HCV-IN-29 is an inhibitor of hepatitis C virus (HCV). (Exacted from patent US8329159B2, compound 1e)
1015073-42-3	Sofosbuvir Impurity 31 PSI-7409, the active 5'-triphosphate metabolite of PSI-7851, is a potent inhibitor of the HCV NS5B RNA dependent RNA polymerase.
1018450-26-4	Fosdevirine Fosdevirine is a highly potent next-generation Anti-HIV nonnucleoside reverse transcriptase inhibitor (NNRTI) with an EC50 of 11 nM. It is a novel and once-daily (QD) inhibitor with activity against efavirenz-resistant strains. It demonstrated potent antiviral activity in treatment-naive HIV-infected subjects, and had favorable PK and resistance profiles. It was originally developed by idenix pharmaceuticals and was in clinical phase 2, but now it has been terminated.
1026785-55-6	Lomibuvir Lomibuvir is an nonnucleoside NS5B polymerase inhibitor. It inhibits the 1b/Con1 HCV subgenomic replicon. It binds to the HCV polymerase with dissociation constants of 17 nM. It demonstrated effective antiviral efficacy and may be used for the treatment of HCV. It was developed by ViroChem Pharma, which was acquired by Vertex Pharmaceuticals in 2009. It is in clinical phase 2 with no progress.
1026785-59-0	VX-222 (VCH-222, Lomibuvir) VX-222 (VCH-222) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM, 15.3-fold less effective for mutant M423T, and 108-fold less effective for mutant I482L. Phase 2.
102841-43-0	b-D-Xylopyranoside,3-(6,7-dihydro-6-hydroxy-7,7-dimethyl-5H-furo[3,2-g][1]benzopyran-2-yl)-5-hydroxyphenyl Antioxidant activity.
1036915-08-8	IDX184 IDX184 is a potent and orally bioavailable HCV replication inhibitor that potently inhibits HCV polymerase with an IC50 of 0.31 μM and a Ki of 52.3 nM.
104987-36-2	Oenothein B Oenothein B is a dimeric macrocyclic ellagitannin with a wide range of pharmacological activities, including antioxidant, anti-inflammatory, anti-fungal, anti-HCV and anti-tumor properties. It is an effective and specific inhibitor of poly(ADP-ribose) glycohydrolase.
1072874-90-8	Miravirsen Miravirsen (SPC-3649), a β-d-oxy-locked nucleic acid-modified phosphorothioate antisense oligonucleotide, inhibit the biogenesis of miR-122. Miravirsen (SPC-3649) is used in the study for HCV infections. Miravirsen is thought to work mainly by hybridizing to mature miR-122 and blocking its interaction with HCV RNA, its target sequence is also present in pri- and pre-miR-122.
107622-80-0	4-Phenoxybenzylamine 4-Phenoxybenzylamine inhibits the function of HCV NS3 protein by stabilizing the inactive conformation with an IC50 of about 500 μM against FL NS3/4a.
1132936-00-5	ABT-072 ABT-072 is a potent and orally active non-nucleoside HCV NS5B polymerase inhibitor with EC50s of 1 nM and 0.3 nM for HCV GT1a and HCV GT1b, respectively.
1132940-11-4	Dasabuvir-sodium Dasabuvir (ABT-333) sodium is a nonnucleoside hepatitis C virus (HCV) polymerase inhibitor. Dasabuvir sodium inhibits RNA-dependent RNA polymerase encoded by the HCV NS5B gene. Dasabuvir sodium inhibits genotype 1a (strain H77) and 1b(strain Con1) replicons, with EC50 values of 7.7 and 1.8 nM, respectively.
1132940-31-8	ABT-072 potassium trihydrate ABT-072 potassium trihydrate is a potent and orally active non-nucleoside HCV NS5B polymerase inhibitor with EC50s of 1 nM and 0.3 nM for HCV GT1a and HCV GT1b, respectively.
1149348-10-6	FGI-106-tetrahydrochloride FGI-106 tetrahydrochloride is a potent and broad-spectrum inhibitor with inhibitory activity against multiple viruses. FGI- 106 tetrahydrochloride is active against Ebola, Rift Valley and Dengue Fever viruses with EC50s of 100 nM, 800 nM and 400-900 nM, respectively. FGI-106 tetrahydrochloride also inhibits non-hemorrhagic fever viruses HCV and HIV-1 with EC50s of 200 nM and 150 nM, respectively.
1169766-14-6	Morin-3-O-β-D-glucopyranoside Morin 3-O-β-D-glucopyranoside is a natural flavonoid with antifungal, anticancer and antioxidant activities. Morin 3-O-β-D-glucopyranoside inhibits reverse transcriptase, protein-tyrosine kinase and xanthine oxidase, and also shows anti-HIV, antiarteriosclerotic, and superoxide scavenging activities.
117824-04-1	Dehydrojuncusol Dehydrojuncusol, a potent HCV inhibitor, targets HCV NS5A and is able to inhibit RNA replication of replicons harboring resistance mutations to anti-NS5A direct-acting antivirals. Dehydrojuncusol significantly inhibits HCV infection when added after virus inoculation of HCV genotype 2a (EC50=1.35 µM).
1192706-52-7	Cepeginterferon alfa-2b
119567-79-2	Taribavirin Taribavirin is an orally active inosine monophosphate dehydrogenase inhibitor that is active against a variety of viruses, particularly hepatitis C virus and influenza virus. It is a ribavirin prodrug designed to cluster in the liver and target hepatitis C virus-infected liver cells while minimizing distribution in red blood cells and the development of hemolytic anemia.
1199809-32-9	PSI-352938

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