Enterovirus (EV)

CAS No.	Product Name	Inquiry
	Fluticasone-propionate-d3 Fluticasone propionate-d3 is the deuterium labeled Fluticasone propionate. Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM.
	Fluticasone-propionate-d5 Fluticasone propionate-d5 is deuterium labeled Fluticasone (propionate). Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM.
	Rupintrivir-d4 Rupintrivir-d4 (AG7088-d4) is the deuterium labeled Rupintrivir. Rupintrivirvr (AG7088), an antiviral drug, is a potent, selective and irreversible inhibitor of human rhinovirus (HRV) 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays, with a mean EC50 of 0.023 μM. Rupintrivirvr shows immune-modulatory effect.
1005036-73-6	(Rac)-Golgicide A (Rac)-Golgicide A is a racemate of Golgicide A, which is a potent, highly specific and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF) GBF1.
107355-45-3	WIN 54954 WIN 54954, an orally active and broad-spectrum anti-picornavirus drug, is effective against human rhinovirus, echovirus 9, and enterovirus infections.
1139889-93-2	Golgicide A Golgicide A causes a decrease in GBF1-mediated Arf1 activation, arrests secretion of soluble and membrane-anchored proteins and then impairs retrograde toxin transport.
1158264-37-9	DC07090 dihydrochloride DC07090 dihydrochloride is a potent, reversible, low toxicity and competitive non-peptide inhibitor of human enterovirus 71 3C protease with an IC50 and a Ki value of 21.72 μM and 23.29 μM. It also inhibits the replication of coxsackievirus A16 (CVA16) with an EC50 value of 27.76 μM.
1193340-31-6	AN-12-H5 AN-12-H5, an antienterovirus compound, targets the replication processes of PV and enterovirus 71 (EV71). AN-12-H5 is a bifunctional, enviroxime-like anti-Enterovirus compound that inhibits replication and the early stage of enterovirus 71 infection with EC50 of 0.55 uM; mutations in capsid proteins (G3112A, VP1-Ala224Thr, and G2396A, VP3-Arg227Lys mutations) are resistant to AN-12-H5.
1198151-75-5	Vapendavir diphosphate Vapendavir diphosphate, an effective enterovirus capsid binder (CB), has strong antiviral activity against the replication of enterovirus 71 (EV71) with EC50s of 0.5-1.4 μM in different EV71 strains.
124436-59-5	Pirodavir R-77975's predecessor, R 61837, a substituted phenyl-pyridazinamine, was effective in inhibiting 80% of 100 serotypes tested (EC80) at concentrations above 32 micrograms/ml, pirodavir inhibits the same percentage of viruses at 0.064 micrograms/ml. Pirodavir is also effective in inhibiting 16 enteroviruses, with an EC80 of 1.3 micrograms/ml. Pirodavir acts at an early stage of the viral replication cycle (up to 40 min after infection) and reduces the yield of selected rhinoviruses 1,000- to 100,000-fold in a single round of replication. Adults with symptoms of < or = 2 days' duration were randomly assigned to intranasal sprays of pirodavir (2 mg per treatment) or placebo six times daily for 5 days. In people with laboratory-documented rhinovirus colds (53 in the pirodavir group, 55 in the placebo group), no significant differences in the resolution of respiratory symptoms were apparent between the groups. The median duration of illness was 7 days in each group. Similarly, scores for individual symptoms found no differences in favor of pirodavir during or after treatment.
1394285-50-7	Golgicide A-2 Golgicide A-2, a Golgicide A (GCA) derivative, is the most active stereoisomer of golgicide A. Golgicide A-2 is a cis-Golgi ArfGEF GBF inhibitor with high selectivity and efficiency in killing An. stephensi larvae. It can be used for research on dengue virus-related diseases.
146949-21-5	Pocapavir Pocapavir has been found to be an antienterovirus agent that could probably be effctive against enterovirus infections. The Phase-II trial for Poliomyelitis has not been reported yet since 2012.
152121-53-4	PD 169316 PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor, with IC50 of 89 nM.
1594427-18-5	Viral-2C-protein-inhibitor-1 Viral 2C protein inhibitor 1 (compound 6aw) is a potent and broad-spectrum enterovirus antiviral agent, inhibiting viral 2C protein. Viral 2C protein inhibitor 1 inhibits multiple strains of EV-D68, EV-A71 and CVB3 with EC50s of 0.1~3.6 µM, and exhibits high selectivity index and relatively low cytotoxicity
17575-22-3	Lanatoside C Lanatoside C is a cardiac glycoside, can be used in the treatment of congestive heart failure and cardiac arrhythmia.Lanatoside C has an IC50 of 0.19 μM for dengue virus infection in HuH-7 cells. Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya, Sindbis virus and the human enterovirus 71.
200937-57-1	Fmoc-Leu-OH-[15N] Fmoc-Leu-OH-[15N] is a labelled L-Leucine-N-FMOC. Leucine is an α-amino acid essential for humans.
207572-66-5	Pirlindole mesylate Pirlindole mesylate is a highly selective reversible inhibitor of monoamine oxidase type A.
223537-30-2	Rupintrivir Rupintrivir is a potent and selective irreversible human rhinovirus (HRV) 3C protease inhibitor (EC50 = 5 nM). It has been demonstrated to have in vitro activity against all HRVs tested, consistent with its interaction with a strictly conserved subset of amino acids in the 3C protease. It blocks processing of viral proteins, thus blocking viral replication.
153168-05-9	Pleconaril Pleconaril is a capsid function inhibitor which targets a conserved hydrophobic pocket of a major viral capsid protein called VP-1. Pleconaril inhibits attachment and virus uncoating.
3258-02-4	EIDD-1931 EIDD-1931 is a ribonucleoside analog that exhibits potential antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV. EIDD-1931 induces mutations in RNA virions, inhibiting SARS-CoV-2 and other coronavirus in mice and human airway epithelial cells.

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