Enterovirus (EV)

CAS No.	Product Name	Inquiry
1193340-31-6	AN-12-H5 AN-12-H5, an antienterovirus compound, targets the replication processes of PV and enterovirus 71 (EV71). AN-12-H5 is a bifunctional, enviroxime-like anti-Enterovirus compound that inhibits replication and the early stage of enterovirus 71 infection with EC50 of 0.55 uM; mutations in capsid proteins (G3112A, VP1-Ala224Thr, and G2396A, VP3-Arg227Lys mutations) are resistant to AN-12-H5.
1198151-75-5	Vapendavir diphosphate Vapendavir diphosphate, an effective enterovirus capsid binder (CB), has strong antiviral activity against the replication of enterovirus 71 (EV71) with EC50s of 0.5-1.4 μM in different EV71 strains.
124436-59-5	Pirodavir R-77975's predecessor, R 61837, a substituted phenyl-pyridazinamine, was effective in inhibiting 80% of 100 serotypes tested (EC80) at concentrations above 32 micrograms/ml, pirodavir inhibits the same percentage of viruses at 0.064 micrograms/ml. Pirodavir is also effective in inhibiting 16 enteroviruses, with an EC80 of 1.3 micrograms/ml. Pirodavir acts at an early stage of the viral replication cycle (up to 40 min after infection) and reduces the yield of selected rhinoviruses 1,000- to 100,000-fold in a single round of replication. Adults with symptoms of < or = 2 days' duration were randomly assigned to intranasal sprays of pirodavir (2 mg per treatment) or placebo six times daily for 5 days. In people with laboratory-documented rhinovirus colds (53 in the pirodavir group, 55 in the placebo group), no significant differences in the resolution of respiratory symptoms were apparent between the groups. The median duration of illness was 7 days in each group. Similarly, scores for individual symptoms found no differences in favor of pirodavir during or after treatment.
1394285-50-7	Golgicide A-2 Golgicide A-2, a Golgicide A (GCA) derivative, is the most active stereoisomer of golgicide A. Golgicide A-2 is a cis-Golgi ArfGEF GBF inhibitor with high selectivity and efficiency in killing An. stephensi larvae. It can be used for research on dengue virus-related diseases.
146949-21-5	Pocapavir Pocapavir has been found to be an antienterovirus agent that could probably be effctive against enterovirus infections. The Phase-II trial for Poliomyelitis has not been reported yet since 2012.
152121-53-4	PD 169316 PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor, with IC50 of 89 nM.
1594427-18-5	Viral-2C-protein-inhibitor-1 Viral 2C protein inhibitor 1 (compound 6aw) is a potent and broad-spectrum enterovirus antiviral agent, inhibiting viral 2C protein. Viral 2C protein inhibitor 1 inhibits multiple strains of EV-D68, EV-A71 and CVB3 with EC50s of 0.1~3.6 µM, and exhibits high selectivity index and relatively low cytotoxicity
17575-22-3	Lanatoside C Lanatoside C is a cardiac glycoside, can be used in the treatment of congestive heart failure and cardiac arrhythmia.Lanatoside C has an IC50 of 0.19 μM for dengue virus infection in HuH-7 cells. Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya, Sindbis virus and the human enterovirus 71.
200937-57-1	Fmoc-Leu-OH-[15N] Fmoc-Leu-OH-[15N] is a labelled L-Leucine-N-FMOC. Leucine is an α-amino acid essential for humans.
2012598-53-5	Vapendavir-d6
207572-66-5	Pirlindole mesylate Pirlindole mesylate is a highly selective reversible inhibitor of monoamine oxidase type A.
223537-30-2	Rupintrivir Rupintrivir is a potent and selective irreversible human rhinovirus (HRV) 3C protease inhibitor (EC50 = 5 nM). It has been demonstrated to have in vitro activity against all HRVs tested, consistent with its interaction with a strictly conserved subset of amino acids in the 3C protease. It blocks processing of viral proteins, thus blocking viral replication.
2237925-62-9	DMA-135-hydrochloride DMA-135 hydrochloride inhibits enterovirus 71 (EV71) IRES-dependent translation and replication. DMA-135 hydrochloride binds to enterovirus 71 (EV71) SLII domain with moderately high affinity (KD= 520 nM). DMA-135 hydrochloride has no significant toxicity in cell-based studies.
23661-03-2	Antiviral agent 24 N6-(3-Trifluoromethylbenzyl)adenosine is a biomedical compound in the research of diverse ailments, exhibiting remarkable potential as an adenosine receptor agonist. Its profound influence on neurotransmitter regulation renders it highly efficacious in studying neurological disorders, cardiovascular afflictions and inflammation-related conditions.
2413648-96-9	EV-A71-IN-1 EV-A71-IN-1 is a human enterovirus A71 (EV-A71) capsid protein inhibitor with an EC50 of 0.27 μM against EV-A71. EV-A71-IN-1 is a capsid binder that blocks the interaction between the viral VP1 and the host receptor hSCARB2. EV-A71-IN-1 inhibits a series of different human enteroviruses without significant cytotoxicity (CC50>56.2 μM).
2420396-84-3	Antiviral-agent-21 Antiviral agent 21 (Compound 4) is an anti-EV71 agent.
2507-55-3	2-Hydroxytetradecanoic acid
2519-30-4	Brilliant black Brilliant black BN, an azo dye and a food colorant, is a promising antiviral drug against EV71 infection by inhibiting the interaction between EV71 and its cellular uncoating factor cyclophilin A.
25379-88-8	Methyl 3,4-dihydroxyphenylacetate
2738376-73-1	Vapendavir-d5 Vapendavir-d5 is the deuterium labeled Vapendavir. Vapendavir (BTA798) is a potent enteroviral capsid binder (CB).

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