Cytomegalovirus (CMV)

CAS No.	Product Name	Inquiry
	Ganciclovir-d5 Ganciclovir-d5 (BW 759-d5) is the deuterium labeled Ganciclovir. Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1).
10212-25-6	2,2'-Cyclocytidine hydrochloride 2,2'-Anhydro-cytidine-HCl is a DNA synthesis inhibitor commonly used as an antineoplastic agent to treat leukemias.
107910-75-8	Ganciclovir Sodium Ganciclovir Sodium is a potent inhibitor of the Herpesvirus family including cytomegalovirus. It is an acyclovir analog. It is used to treat complications from AIDS-associated cytomegalovirus infections. It was developed by Roche and has been listed.
1113044-49-7	FIT-039 FIT-039 is a potent and selective inhibitor of cyclin-dependent kinase 9 (CDK9), which suppresses replication of a broad spectrum of DNA viruses through inhibition of mRNA transcription.
113852-41-8	PMEDAP PMEDAP is a potent inhibitor of human immunodeficiency virus (HIV) replication with anti-murine cytomegalovirus (MCMV) activity, and is a very potent inhibitor of moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality. It has been studied for potential treatment of feline herpesvirus 1 (FHV-1).
1222800-79-4	ML324 ML324 exhibits good Caco-2 cell permeability, and possesses excellent microsomal stability in the presence of both mouse and rat liver microsomes.
175865-59-5	Valganciclovir HCl Valganciclovir hydrochloride hydrate is an antiviral used to treat cytomegalovirus infection. It is the prodrug of ganciclovir, a synthetic analog of 2'-deoxy-guanosine which is phosphorylated to a dGTP analog that competitively inhibits the incorporation of dGTP by viral DNA polymerase.
113852-37-2	Cidofovir Cidofovir is inhibitory to CMV plaque formation even when added to the cells at 48 hr post infection with IC50 of 0.9 μg/mL for Davis and 1.6 μg/mL for AD-169 strains,respectively.
444805-28-1	CMX 001 CMX 001 is an antiviral inhibitor, working against BK polymavirus replication in primary human urothelial cells.An alkoxyalkyl ester prodrug containing the synthetic, acyclic nucleoside monophosphate analog cidofovir linked, through its phosphonate group, to a lipid, 3-hexadecyloxy-1-propanol, with antiviral activity against double-stranded DNA viruses.
917389-32-3	Letermovir Letermovir is a novel anti-CMV compound which targets the pUL56 (amino acid 230-370) subunit of the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors. It has a novel mode of action targets the enzyme UL56 terminase and keep active to other drug-resistant virus. It has been approved in prophylaxis of CMV infection and disease in adult CMV-seropositive recipients of an allogeneic hematopoietic stem cell transplant (HSCT).
149394-66-1	Cidofovir dihydrate Cidofovir is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. It is an acyclic nucleoside phosphonate, and is therefore independent of phosphorylation by viral enzymes, unlike acyclovir. Cidofovir was discovered at the Institute of Organic Chemistry and Biochemistry, Prague, and developed by Gilead Sciences and is marketed with the brand name Vistide by Gilead in the USA, and by Pfizer elsewhere. Maintenance therapy with cidofovir involves an infusion only once every two weeks, making it a convenient treatment option. Because dosing is relatively infrequent, a permanent catheter is not necessary for infusions.
55319-36-3	Soyasaponin II Soyasaponin II is found in Glycine max, it shows antiviral effects.
6754-58-1	Xanthohumol Xanthohumol is a prenylated flavonoid isolated from Hops (Humulus lupulus L.), displaying anticancer and anti-angiogenic properties. It acts as an inhibitor of DGAT, COX-1 and COX-2.

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