Zotatifin

Category	SARS-CoV
CAS	2098191-53-6
Description	Zotatifin is a selective eIF4A inhibitor that increases the affinity between eIF4A and specific polypurine sequence motifs and has been reported to inhibit translation of driver oncogenes in models of lymphoma.

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Synonyms	rel-Zotatifin; EFT226; EFT-226; EFT 226
IUPAC Name	4-[(2S,3R,4S,5S,6R)-4-[(dimethylamino)methyl]-2,3-dihydroxy-10,12-dimethoxy-5-phenyl-7-oxa-11-azatricyclo[6.4.0.02,6]dodeca-1(12),8,10-trien-6-yl]benzonitrile
Molecular Weight	487.5
Molecular Formula	C28H29N3O5
Canonical SMILES	CN(C)CC1C(C2(C(C1O)(C3=C(N=C(C=C3O2)OC)OC)O)C4=CC=C(C=C4)C#N)C5=CC=CC=C5
InChI	InChI=1S/C28H29N3O5/c1-31(2)16-20-23(18-8-6-5-7-9-18)28(19-12-10-17(15-29)11-13-19)27(33,25(20)32)24-21(36-28)14-22(34-3)30-26(24)35-4/h5-14,20,23,25,32-33H,16H2,1-4H3/t20-,23-,25-,27+,28+/m1/s1
InChIKey	QYCXWOACFWMQFO-WZWZCULESA-N
Purity	98% by HPLC
Solubility	In vitro: 10 mM in DMSO
Appearance	White to Off-white Solid
Storage	Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month
Complexity	819
Exact Mass	487.21072103
Target	Eukaryotic Initiation Factor (eIF); SARS-CoV; Apoptosis
XLogP3-AA	2.4