Zotatifin

Category	SARS-CoV
CAS	2098191-53-6
Description	Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5'-UTRs (IC50=2 nM) and interferes with the assembly of the eIF4F initiation complex. Zotatifin shows robust antiviral effects, it effectively reduces viral infectivity by inhibiting SARS-CoV-2 NP protein biogenesis (IC90=37 nM). Zotatifin induces cell Apoptosis.

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Synonyms	Zotatifin\|EFT226\|2098191-53-6\|EFT-226\|UNII-2EWN8Z05CN\|2EWN8Z05CN\|4-((5aR,6S,7S,8R,8aS)-7-((Dimethylamino)methyl)-8,8a-dihydroxy-1,3-dimethoxy-6-phenyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[4,5]furo[3,2-c]pyridin-5a-yl)benzonitrile\|rel-Zotatifin\|Zotatifin [INN]\|4-((5aR,6S,7S,8R,8aS)-7-((Dimethylamino)methyl)-8,8a-dihydroxy-1,3-dimethoxy-6-phenyl-6,7,8,8a-tetrahydro-5ah-cyclopenta(4,5)furo(3,2-C)pyridin-5a-yl)benzonitrile\|Zotatifin [USAN]\|Zotatifin (USAN/INN)\|CHEMBL4303782\|SCHEMBL18864788\|EX-A4623\|BDBM50540861\|NSC818001\|NSC828584\|WHO 10998\|NSC-818001\|NSC-828584\|HY-112163\|CS-0043584\|D11837\|A937238\|4-[(2S,3R,4S,5S,6R)-4-[(dimethylamino)methyl]-2,3-dihydroxy-10,12-dimethoxy-5-phenyl-7-oxa-11-azatricyclo[6.4.0.02,6]dodeca-1(12),8,10-trien-6-yl]benzonitrile\|Benzonitrile, 4-((5aR,6S,7S,8R,8aS)-7-((dimethylamino)methyl)-6,7,8,8a-tetrahydro-8,8a-dihydroxy-1,3-dimethoxy-6-phenyl-5ah-cyclopenta(4,5)furo(3,2-C)pyridin-5a-yl)-
Molecular Weight	487.55
Molecular Formula	C28H29N3O5
Canonical SMILES	CN(C)CC1C(C2(C(C1O)(C3=C(N=C(C=C3O2)OC)OC)O)C4=CC=C(C=C4)C#N)C5=CC=CC=C5
Purity	99.58%
Solubility	In vitro: 10 mM in DMSO
Appearance	White to off-white (Solid)
Storage	Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month
Complexity	819
Exact Mass	487.21072103
Target	Eukaryotic Initiation Factor (eIF); SARS-CoV; Apoptosis
XLogP3-AA	2.4