ZCL278

Category	Dengue virus
CAS	587841-73-4
Description	ZCL 278 is a cell-permeable inhibitor of Cdc42, a Rho family GTPase. It binds into the surface groove on Cdc42 (Kd = 6.4-11.4 µM), blocking interaction with intersectin (ITSN), a guanine nucleotide exchange factor (GEF).

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Product Information

Synonyms	587841-73-4;ZCL278;ZCL 278;ZCL-278;2-(4-bromo-2-chlorophenoxy)-N-(4-(N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl)phenylcarbamothioyl)acetamide;2-(4-bromo-2-chlorophenoxy)-N-((4-(N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)acetamide;2-(4-bromo-2-chlorophenoxy)-N-[[4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl]carbamothioyl]acetamide;1-[2-(4-BROMO-2-CHLOROPHENOXY)ACETYL]-3-{4-[(4,6-DIMETHYLPYRIMIDIN-2-YL)SULFAMOYL]PHENYL}THIOUREA;2-(4-bromo-2-chlorophenoxy)-N-({4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl}carbamothioyl)acetamide;2-(4-bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]-acetamide;4-[({[(4-bromo-2-chlorophenoxy)acetyl]amino}carbothioyl)amino]-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide;C21H19BrClN5O4S2;CHEMBL4303380;SCHEMBL14060769;EX-A216;HMS3653A10;AMY24209;BCP08398;ZCL 278?;MFCD03623090;s7293;STK125289;AKOS000494749;CCG-270148;CS-1731;SB19477;NCGC00371139-01;NCGC00371139-12;AC-32668;AS-74805;DA-42020;HY-13963;SW219702-1;EN300-128420;A869366;AN-329/41770289;BRD-K22829793-001-01-0;BRD-K22829793-001-02-8;BRD-K22829793-001-03-6;Z57396845;
IUPAC Name	2-(4-bromo-2-chlorophenoxy)-N-[[4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl]carbamothioyl]acetamide
Molecular Weight	235.24
Molecular Formula	C10H13N5O2
Canonical SMILES	C1C[C@@H](O[C@@H]1CO)N2C=NC3=C(N=CN=C32)N
InChI	InChI=1S/C21H19BrClN5O4S2/c1-12-9-13(2)25-20(24-12)28-34(30,31)16-6-4-15(5-7-16)26-21(33)27-19(29)11-32-18-8-3-14(22)10-17(18)23/h3-10H,11H2,1-2H3,(H,24,25,28)(H2,26,27,29,33)
InChIKey	XKZDWYDHEBCGCG-UHFFFAOYSA-N
Appearance	Solid