Xylan polysulfate

Category	Human immunodeficiency Virus (HIV)
CAS	37300-21-3
Description	Xylan polysulfate is a semi-synthetic polysulfated xylan as a sulfated pentose polysaccharide with heparin-like properties.

Quotation Now

Synonyms	Xylan, hydrogen sulfate; SR 25493; Xylan sulfate; Xylofuranan sulfate; β-D-Xylan, (1→4)-, 2,3-bis(hydrogen sulfate)
Purity	≥98%
Solubility	Soluble in DMSO
Appearance	Solid powder
Shelf Life	As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly.
Storage	Store at -20 °C
Complexity	1140
Exact Mass	601.92234227
In Vitro	Pentosan polysulfate has been shown to inhibit HIV-1 activity with an ED50 of 0.19 μg/mL in MT-4 cells. It inhibits HIV-1 antigen expression in HUT-78 cells at an ED50 of 0.02 μg/mL, and complete inhibition of HIV-1 antigen expression is obtained at a concentration of 4.0 μg/mL. Pentosan Polysulfate suppresses NF-κB, decreases the proinflammatory actions of TNFα, and decreases high glucose and advanced glycation end products (AGEs) stimulated MCP-1 production.
In Vivo	Pentosan polysulfate has been shown to decreases interstitial inflammation and glomerulosclerosis in 5/6 nephrectomized rats. Pentosan polysulfate treatment preserves renal function, significantly reduces albuminuria, and markedly decreases the severity of renal lesions, including tubulointerstitial inflammation. Pentosan polysulfate also reduces upregulation of TNFα and proinflammatory genes in aging diabetic kidneys.
Target	HIV
XLogP3-AA	-5.6