Viramidine Hydrochloride

Category	Hepatitis B Virus (HBV)
CAS	40372-00-7
Description	Taribavirin hydrochloride is an orally active inosine monophosphate dehydrogenase inhibitor, has activity against a wide range of viruses, especially the hepatitis C virus and influenza virus. Taribavirin hydrochloride is a Ribavirin prodrug, is designed to concentrate within the liver to target HCV-infected hepatocytes while minimizing distribution within red blood cells (RBCs) and the development of hemolytic anemia.

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Synonyms	1-β-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboximidamide Monohydrochloride; AVS 206; ICN 3142; Ribamidine Hydrochloride; Taribavirin Hydrochloride
IUPAC Name	1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboximidamide;hydrochloride
Molecular Weight	279.68
Molecular Formula	C8H14ClN5O4
Canonical SMILES	C1=NC(=NN1C2C(C(C(O2)CO)O)O)C(=N)N.Cl
InChI	InChI=1S/C8H13N5O4.ClH/c9-6(10)7-11-2-13(12-7)8-5(16)4(15)3(1-14)17-8;/h2-5,8,14-16H,1H2,(H3,9,10);1H/t3-,4-,5-,8-;/m1./s1
InChIKey	PIGYMBULXKLTCJ-UHSSARMYSA-N
Melting Point	167-172°C
Purity	98%
Solubility	DMSO (Slightly, Heated); Methanol (Slightly)
Appearance	White Solid
Application	Antiviral Agents
Storage	4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture)
In Vitro	Taribavirin hydrochloride (0-2 μM; 24 hours) significantly induces MCF-7 cell death, recording half inhibitory effect (IC50) of 0.756 μM in MCF-7 cells.
PSA	150.50000
Target	HBV; HCV