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Valproic acid
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 99-66-1 |
| Description | Valproic acid is an inhibitor of histone deacetylase (HDAC) inhibitor, which has an anticancer effect. Valproic acid was shown to induce proliferation and enhance self-renewal of hematopoietic stem cells (HSC). |
Product Information
| Synonyms | VPA; 2-Propylpentanoic Acid |
| IUPAC Name | 2-propylpentanoic acid |
| Molecular Weight | 144.21 |
| Molecular Formula | C8H16O2 |
| Canonical SMILES | CCCC(CCC)C(=O)O |
| InChI | InChI=1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10) |
| InChIKey | NIJJYAXOARWZEE-UHFFFAOYSA-N |
| Boiling Point | 220.0±0.0 °C at 760 mmHg |
| Melting Point | 25 °C |
| Flash Point | 232 °F |
| Purity | >98% |
| Density | 0.9±0.1 g/cm3 |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | Colorless to light yellow (Liquid) |
| Application | Antimanic Agents |
| Storage | Powder: -20°C: 3 years; 4°C: 2 years In solvent: -80°C: 6 months; -20°C: 1 month |
| Complexity | 93.4 |
| Exact Mass | 144.115029749 |
| Index Of Refraction | 1.435 |
| In Vitro | Valproic acid (VPA) (0-15 mM; 24 and 72 h) inhibits Hela cell growth in a dose- and time- dependent manner. Valproic acid (10 mM; 24 h) significantly attenuates the activities of total, cytosol and nuclear HDACs. Valproic acid (0-15 mM; 24 h) induces a G1 phase arrest at 1-3 mM and a G2/M phase arrest at 10 mM, and increases the percentage of sub-G1 cells in HeLa cells. Valproic acid also induces necrosis, Apoptosis and Lactate dehydrogenase (LDH) release. Valproic acid (0-20 mM; 24 h) activates Tcf/Lef-dependent transcription and synergizes with lithium. Valproic acid (0-5 mM; 0-18 h) increases β-catenin levels in Neuro2A cells. Valproic acid (0-2 mM; 0-24 h) stimulates phosphorylation of AMPK and ACC in hepatocytes. Valproic acid (0-10 mM; 2 days) induces Notch1 signaling and morphologic differentiation, suppresses production of NE tumor markers in SCLC cells. |
| In Vivo | Valproic acid (VPA) (500 mg/kg; i.p.; daily for 12 days) inhibits tumor angiogenesis in mice transplanted with Kasumi-1 cells. Valproic acid (350 mg/kg; i.p.; once) enhances social behavior in rats. Valproic acid (0.26% (w/v); p.o. via drinking water; 14 days) decreases liver mass, hepatic fat accumulation, and serum glucose in obese mice without hepatotoxicity. |
| PSA | 37.30000 |
| Target | HDAC; Autophagy; Mitophagy; HIV; Notch; Apoptosis; Endogenous Metabolite |
| Vapor Pressure | 0.0±0.9 mmHg at 25°C |
| XLogP3-AA | 2.8 |
