Umifenovir

Category	Hepatitis B Virus (HBV)
CAS	131707-25-0
Description	Arbidol is an antiviral agent using for the treatment of influenza infection in Russia and China. It inhibits membrane fusion and prevents contact between the virus and target host cells. Fusion between the viral capsid and the cell membrane of the target cell is inhibited and this prevents viral entry to the target cell. Although some Russian studies have shown it to be effective, it is not approved for use in Western countries.

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Product Information

Synonyms	Arbidol; 6-Bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-1H-indole-3-carboxylic Acid Ethyl Ester
IUPAC Name	ethyl 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate
Molecular Weight	477.41
Molecular Formula	C22H25BrN2O3S
Canonical SMILES	CCOC(=O)C1=C(N(C2=CC(=C(C(=C21)CN(C)C)O)Br)C)CSC3=CC=CC=C3
InChI	InChI=1S/C22H25BrN2O3S/c1-5-28-22(27)20-18(13-29-14-9-7-6-8-10-14)25(4)17-11-16(23)21(26)15(19(17)20)12-24(2)3/h6-11,26H,5,12-13H2,1-4H3
InChIKey	KCFYEAOKVJSACF-UHFFFAOYSA-N
Boiling Point	591.8±50.0°C (Predicted)
Flash Point	311.7±30.1 °C
Purity	≥95%
Density	1.37±0.1 g/cm3 (Predicted)
Solubility	Soluble in Chloroform (Slightly), Methanol (Slightly, Heated)
Appearance	Pale Brown to Light Brown Solid
Storage	Store at -20°C under inert atmosphere
Complexity	546
Exact Mass	476.076904
Index Of Refraction	1.620
In Vitro	Umifenovir exhibits a wide range and potent antiviral activity against a number of viruses including Influenza Viruses A, B and C, respiratory syncytial virus, SARS-CoV, adenovirus, parainfluenza type 5, poliovirus 1, rhinovirus 14, coxsackievirus B5, hantaan virus, Chikungunya virus, HBV and HCV.
In Vivo	Umifenovir (25 and 45 mg/ml; p.o.;) shows a survival benefit to mice suffering from influenza infection. Oral administration Result: Increased the survival rate, inhibited the decrease of body weight at 45 mg/mL and inhibited the increase of mice lung index at 25 mg/mL and 45 mg/mL comparing to virus group.
PSA	80.00000
Target	Influenza Viruses A, B and C, respiratory syncytial virus, SARS-CoV, adenovirus, parainfluenza type 5, poliovirus 1, rhinovirus 14, coxsackievirus B5, hantaan virus, Chikungunya virus, HBV and HCV
Vapor Pressure	0.0±1.7 mmHg at 25°C
XLogP3-AA	4.4