Tulobuterol hydrochloride

Category	Influenza Virus
CAS	56776-01-3
Description	Tulobuterol hydrochloride is a salt form of Tulobuterol, which is a long-acting beta2-adrenergic receptor agonist.

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Product Information

Synonyms	2-tert-Butylamino-1-(2-chlorophenyl)-ethanol hydrochloride
Molecular Weight	264.19
Molecular Formula	C12H19Cl2NO
Canonical SMILES	CC(C)(C)NCC(C1=CC=CC=C1Cl)O.Cl
InChI	InChI=1S/C12H18ClNO.ClH/c1-12(2,3)14-8-11(15)9-6-4-5-7-10(9)13;/h4-7,11,14-15H,8H2,1-3H3;1H
InChIKey	RSLNRVYIRDVHLY-UHFFFAOYSA-N
Boiling Point	338.2°C at 760 mmHg
Melting Point	163°C
Flash Point	158.3°C
Purity	99.69%
Density	1.098 g/cm3
Solubility	In Vitro: DMSO : ≥ 100 mg/mL (378.52 mM)
Appearance	White to off-white (Solid)
Storage	4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture)
Animal Admin	Experiments are performed on 50 BALB/c mice weighing 21.7±0.2 g, which are divided into 2 groups. In the transdermal Tulobuterol treatment group, a small piece (4×4 mm2) of a 0.5 mg Tulobuterol patch sheet (16×16 mm2) is affxed to the shaved back of each animal and covered with a small adhesive strip. To examine the effect of transdermal Tulobuterol treatment, the diaphragm muscles of mice immediately after E.coli Endotoxin (20 mg/kg) administration are dissected and measured for contractility at 0, 12, and 24 h (n=5 each) after patch affxation, termed T0E0, T12E0, and T24E0, respectively; to examine such effect 4 h after E.coli Endotoxin (20 mg/kg) injection, the diaphragm muscles of another group of mice are dissected and measured for contractility at 0+4,12+4,and 24+4 h (n=5 each) after patch affxation,termed T0E4, T12E4, and T24E4, respectively.
Complexity	191
Exact Mass	263.0843696
In Vitro	Treatment of the cells with Tulobuterol (0.1 μM) significantly decreases the viral titers of RV14 in the supernatants from 12 h after infection compared with the titers in the cells treated with vehicle (0.001% ethanol). Tulobuterol reduces RV14 release in a concentration-dependent manner. Pretreatment of the cells with Tulobuterol reduces the viral titers of RV14 in the supernatants at concentrations of 0.1 μM or greater.
In Vivo	Tulobuterol, a sympathomimetic drug used as a transdermal patch, increases normal diaphragm muscle strength. In vivo effect of Tulobuterol is examined the on the contractility of diaphragm muscles prepared from mice treated with Endotoxin. In the in vivo treatment, E0 and E4 diaphragm muscles are analyzed at 0, 12, and 24 h after transdermal Tulobuterol treatment. The force-frequency curves of E0 and E4 diaphragm muscles at three time points are not significantly changed each other, indicating that Tulobuterol patch restores the muscle contractility. Thus, diaphragm muscle contractility is maintained during 4 h of Endotoxin administration with Tulobuterol patch for over 24 h.
PSA	32.26000
Target	β2-adrenoceptor