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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
Tubercidin
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| Category | Virus Protease |
| CAS | 69-33-0 |
| Description | Tubercidin is an adenosine analog with antiviral, antitrypanosomal, and antifungal properties. It inhibits DNA/RNA synthesis and other metabolic processes. |
Product Information
| Synonyms | 7-Deazaadenosine; Antibiotic XK 101-1; BRN 0038498; 7-Deaza ribo Adenosine; 7-β-D-Ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine; 4-Amino-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine; 6-Amino-9-D-ribofuranosyl-7-desazapurine; N7-Deazaadenosine; NQZ-003; NSC 56408; Sparsamycin A; Sparsomycin A; Tubercidine; U 10071 |
| IUPAC Name | (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol |
| Molecular Weight | 266.25 |
| Molecular Formula | C11H14N4O4 |
| Canonical SMILES | C1=CN(C2=NC=NC(=C21)N)C3C(C(C(O3)CO)O)O |
| InChI | InChI=1S/C11H14N4O4/c12-9-5-1-2-15(10(5)14-4-13-9)11-8(18)7(17)6(3-16)19-11/h1-2,4,6-8,11,16-18H,3H2,(H2,12,13,14)/t6-,7-,8-,11-/m1/s1 |
| InChIKey | HDZZVAMISRMYHH-KCGFPETGSA-N |
| Boiling Point | 648.8±55.0 °C at 760 mmHg |
| Melting Point | 247-248 °C (dec.) |
| Purity | ≥98% by HPLC |
| Density | 1.90±0.1 g/cm3 |
| Solubility | Soluble in Methanol |
| Appearance | White Crystalline Powder |
| Application | 7-Deaza-adenosine is an adenosine analog. |
| Shelf Life | As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly |
| Storage | Store at-20°C |
| Complexity | 334 |
| Exact Mass | 266.10150494 |
| In Vitro | Tubercidin (7-Deazaadenosine) (0-10 nM; 14 days) has a dose-dependent inhibitory effect on myeloid and erythroid human bone marrow progenitor cells, and the IC50s of tubercidin were 3.4 nM and 3.7 nM for CFU-GM and BFU-E, respectively. Cell Cytotoxicity Assay Cell Line: Human bone marrow progenitor cells Concentration: 0-10 Incubation Time: 14 days Result: Had a dose-dependent inhibitory effect for CFU-GM and BFU-E |
| In Vivo | Tubercidin (7-Deazaadenosine) (intraperitoneal injection; 5 mg/kg; 10 days) in cooperation with NBMPR-P protects the mice from the lethality of tubercidin and allowed the repetition of the regimen for a second time with 100% survival. |
| PSA | 126.65000 |
| Target | Bacterial; DNA/RNA Synthesis; Influenza Virus; Antibiotic |
| XLogP3-AA | -1.3 |
