TTP-8307

Category	Enterovirus (EV)
CAS	950225-08-8
Description	TTP-8307, a potent inhibitor of several rhino- and enteroviruses replication, inhibits coxsackievirus B3 (CVB3; EC50 = 1.2 μM) and poliovirus by interfering with the synthesis of viral RNA, and exerts antiviral activity through oxysterol-binding protein (OSBP).

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Synonyms	Benzamide, N-[(1R)-1-(4-fluorophenyl)ethyl]-3-[2-(3-isoquinolinyl)-1H-imidazol-5-yl]-; N-[(1R)-1-(4-Fluorophenyl)ethyl]-3-[2-(3-isoquinolinyl)-1H-imidazol-5-yl]benzamide
IUPAC Name	N-[(1R)-1-(4-fluorophenyl)ethyl]-3-(2-isoquinolin-3-yl-1H-imidazol-5-yl)benzamide
Molecular Weight	436.48
Molecular Formula	C27H21FN4O
Canonical SMILES	CC(C1=CC=C(C=C1)F)NC(=O)C2=CC=CC(=C2)C3=CN=C(N3)C4=CC5=CC=CC=C5C=N4
InChI	InChI=1S/C27H21FN4O/c1-17(18-9-11-23(28)12-10-18)31-27(33)21-8-4-7-20(13-21)25-16-30-26(32-25)24-14-19-5-2-3-6-22(19)15-29-24/h2-17H,1H3,(H,30,32)(H,31,33)/t17-/m1/s1
InChIKey	SIBDJDZVNXVLEX-QGZVFWFLSA-N
Boiling Point	743.0±60.0°C at 760 mmHg
Purity	≥95%
Density	1.3±0.1 g/cm3
Solubility	Soluble in DMSO
Appearance	White to light yellow (Solid)
Storage	Store at -20°C
Complexity	654
Exact Mass	436.16993947
In Vitro	TTP-8307 targets the nonstructural protein 3A, inhibits the replication of coxsackievirus B3 (CVB3 Nancy) with EC50 of 1.2 M. TTP-8307 inhibits the replication of coxsackievirus B3 and the three poliovirus Sabin strains, as well as coxsackieviruses A16 and A21 (EC50 of 0.85 and 5.34 μM). TTP-8307 inhibits human rhinoviruses (HRVs) 2, 29, 39, 45, 63, and 85. Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307. TTP-8307 inhibits OSBP-dependent viruses encephalomyocarditis virus (EMCV) and HCV.
Target	Enterovirus; DNA/RNA Synthesis; HCV
XLogP3-AA	4.9