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Antiviral API
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Tris(4-aminophenyl)methane
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| Category | Hepatitis C Virus (HCV) |
| CAS | 548-61-8 |
| Description | Tris(4-aminophenyl)methane is a weak hepatitis C virus (HCV) helicase inhibitor and a triphenylmethane dye. |
Product Information
| Synonyms | Leucopararosaniline; 4,4',4''-Methanetriyltrianiline; 4-[Bis(4-aminophenyl)methyl]phenylamine; 4,4',4''-Methylidynetris[benzenamine]; Leucoparafuchsin; Leucoparafuchsine; Pararosaniline, Leuco Base; Tris(p-aminophenyl)methane; p,p',p''-Triaminotriphenylmethane |
| IUPAC Name | 4-[bis(4-aminophenyl)methyl]aniline |
| Molecular Weight | 289.37 |
| Molecular Formula | C19H19N3 |
| Canonical SMILES | C1=CC(=CC=C1C(C2=CC=C(C=C2)N)C3=CC=C(C=C3)N)N |
| InChI | InChI=1S/C19H19N3/c20-16-7-1-13(2-8-16)19(14-3-9-17(21)10-4-14)15-5-11-18(22)12-6-15/h1-12,19H,20-22H2 |
| InChIKey | ADUMIBSPEHFSLA-UHFFFAOYSA-N |
| Boiling Point | 540.9±45.0°C at 760 mmHg |
| Melting Point | 208°C |
| Flash Point | 316.7°C |
| Purity | ≥95% |
| Density | 1.208±0.1 g/cm3 |
| Solubility | Soluble in DMSO |
| Appearance | Solid |
| Storage | Store at 2-8°C, protect from light |
| Index Of Refraction | 1.701 |
| In Vitro | Tris(4-aminophenyl)methane (Compound 8) shows weak HCV helicase inhibition (30% inhibition at 100 μM). To preserve RNA in a biological sample for analysis, the sample is incubated with an RNA preservative capable of precipitating RNA in an aqueous solution, such as a triphenylmethane dye (e.g., methyl green, crystal violet, pararosaniline, or Tris(4-aminophenyl)methane), cresyl violet, or cobalt ions. RNA preservation may be used in an immunostaining assay and other histochemical methods. |
| PSA | 78.06000 |
| Target | HCV helicase |