Trimethobenzamide hydrochloride

Category	Influenza Virus
CAS	554-92-7
Description	Trimethobenzamide hydrochloride is the hydrochloride salt form of trimethobenzamide, which is a benzamide derivative with antiemetic property. It is an orally available, antiemetic agent used in the therapy of nausea and vomiting and gastrointestinal, viral and other illnesses. It is generally considered the most potent antiemetic that does not have effects on the serotonergic, dopaminergic, or histaminergic systems. It inhibits the chemoreceptor trigger zone (CTZ), an area in the medulla oblongata through which emetic impulses are conveyed to the vomiting center, thereby suppressing nausea and vomiting. It is also used in the treatment of Parkinson's disease. It has been withdrawn from the market.

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Product Information

Synonyms	Ro 2-9578; Tebamide; Ticon; Trimethobenzamide monohydrochloride; N-(p-(2-(dimethylamino)ethoxy)benzyl)-3,4,5-trimethoxybenzamide hydrochloride; Ametik hydrochloride; 4-(2-Dimethylaminoethoxy)-N-(3,4,5-trimethoxybenzoyl)benzylamine Hydrochloride; Anaus; Tigan Hydrochloride; Xametina
IUPAC Name	N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxybenzamide;hydrochloride
Molecular Weight	424.92
Molecular Formula	C21H29ClN2O5
Canonical SMILES	CN(C)CCOC1=CC=C(C=C1)CNC(=O)C2=CC(=C(C(=C2)OC)OC)OC.Cl
InChI	InChI=1S/C21H28N2O5.ClH/c1-23(2)10-11-28-17-8-6-15(7-9-17)14-22-21(24)16-12-18(25-3)20(27-5)19(13-16)26-4;/h6-9,12-13H,10-11,14H2,1-5H3,(H,22,24);1H
InChIKey	WIIZEEPFHXAUND-UHFFFAOYSA-N
Boiling Point	506.9°C at 760mmHg
Melting Point	187.5-190 °C
Purity	98%
Density	1.131g/cm3
Solubility	Soluble in DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Appearance	White Solid
Application	Trimethobenzamide hydrochloride is an orally available, antiemetic agent used in the therapy of nausea and vomiting and gastrointestinal, viral and other illnesses. It is also used in the treatment of Parkinson's disease.
Storage	Store at 2-8°C
Complexity	440
Exact Mass	424.1764997
In Vitro	Trimethobenzamide is a (non-phenothiazine) benzamide antiemetic that acts centrally to block D2 receptors, thereby inhibiting the medullary chemoreceptor trigger zone by blocking emetic impulses to the vomiting center.
In Vivo	The oral bioavailability of Trimethobenzamide is 60% to 100%. The time to peak is about 45 minutes after oral administration and; Intramuscular (I.M.) administration about 30 minutes after intramuscular administration.
PSA	69.26000
Target	Dopamine Receptor; Influenza Virus