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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
Trifluridine
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| Category | Herpes simplex Virus (HSV) |
| CAS | 70-00-8 |
| Description | Trifluorothymidine (TFT) and is an inhibitor of thymidine phosphorylase. TFT also inhibits thymidylate synthase (TS), a rate-limiting enzyme of DNA biosynthesis, and is incorporated into DNA. |
Product Information
| Synonyms | 5-Trifluoromethyl-2'-deoxyuridine; Trifluorothymidine; FTD; 5-Trifluorothymidine; NSC 529182; NSC 75520; Viroptic; α,α,α-Trifluorothymidine; 2'-Deoxy-5-(trifluoromethyl)uridine; Trifluoromethyldeoxyuridine; Trifluridina; Virophta; TFDU |
| IUPAC Name | 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(trifluoromethyl)pyrimidine-2,4-dione |
| Molecular Weight | 296.20 |
| Molecular Formula | C10H11F3N2O5 |
| Canonical SMILES | C1C(C(OC1N2C=C(C(=O)NC2=O)C(F)(F)F)CO)O |
| InChI | InChI=1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1 |
| InChIKey | VSQQQLOSPVPRAZ-RRKCRQDMSA-N |
| Melting Point | 170-172°C |
| Purity | ≥95% |
| Density | 1.646 g/cm3 |
| Solubility | Soluble in DMSO (Slightly), Methanol (Slightly) |
| Appearance | White to off-white crystalline powder |
| Storage | Store at 2-8°C |
| Complexity | 464 |
| Exact Mass | 296.06200594 |
| Index Of Refraction | 1.534 |
| PSA | 104.55000 |
| Target | Thymidylate Synthase; HSV; Nucleoside Antimetabolite/Analog; Orthopoxvirus |
| XLogP3-AA | -0.5 |
