Triazavirin

Category	Influenza Virus
CAS	928659-17-0
Description	Triazavirin is a broad-spectrum antiviral drug, effective against various strains of the Influenza A virus. Triazavirin inhibits the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin might be a potential treatment for SARS-CoV-2.

Quotation Now

Synonyms	TZV; Riamilovir
IUPAC Name	sodium;7-methylsulfanyl-3-nitro-[1,2,4]triazolo[5,1-c][1,2,4]triazin-4-olate;dihydrate
Molecular Weight	286.2
Molecular Formula	C5H7N6NaO5S
Canonical SMILES	CSC1=NN2C(=C(N=NC2=N1)[N+](=O)[O-])[O-].O.O.[Na+]
InChI	InChI=1S/C5H4N6O3S.Na.2H2O/c1-15-5-6-4-8-7-2(11(13)14)3(12)10(4)9-5;;;/h12H,1H3;;2*1H2/q;+1;;/p-1
InChIKey	GDVSBVWTWGUDAW-UHFFFAOYSA-M
Purity	99.12%
Solubility	In Vitro: DMSO : 125 mg/mL (436.76 mM; Need ultrasonic)
Appearance	Light yellow to yellow (Solid)
Storage	4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture)
Complexity	262
Exact Mass	286.00963280
In Vitro	The efficacy of Triazavirin against the tick-borne encephalitis virus is estimated in the sensitive cell culture. In a concentration of 128 mcg/mL Triazavirin is shown active in inhibition of the tick-borne encephalitis virus reproduction (strain Sofiin) by accumulation in the SKEV cell culture.
In Vivo	The therapeutic efficacy Triazavirin against experimental Forest-Spring encephalitis on albino mice is studied. The results shows that in high doses (200-400 mg/kg) Triazavirin moderately protects the infected animals. A significant increase of the animal lifespan in the test groups (from 4.1 to 4.8 days) and a statistically valid decrease of the virus accumulation in the target organ are observed.
Target	Nucleoside Antimetabolite/Analog; Influenza Virus; DNA/RNA Synthesis