α-Tocopherol

Category	Influenza Virus
CAS	59-02-9
Description	α-Tocopherol is a form of vitamin E that is preferentially absorbed and accumulated in humans. α-Tocopherol shows antioxidation effect. It is a potent inhibitor of phorbol ester induced shape change of erythroand megakaryoblastic leukemia cells. It has the function of whitening, preventing skin aging, regulating endocrine, preventing three high and thrombosis, so it is widely used in food, nutrition and health products and cosmetics, and other fields. It is used for the prevention of abortion caused by vitamin E deficiency, habitual abortion and threatened abortion, and also for the treatment of infertility and nutritional giant cell anemia in infants.

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Product Information

Synonyms	(2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol; (+)-α-Tocopherol; (all-R)-α-Tocopherol; 5,7,8-Trimethyltocol; Acros; Almefrol; Biopass E 20; d-α-Tocopherol; Optovit; Tocovital; α-Vitamin E
IUPAC Name	(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol
Molecular Weight	430.70
Molecular Formula	C29H50O2
Canonical SMILES	CC1=C(C2=C(CCC(O2)(C)CCCC(C)CCCC(C)CCCC(C)C)C(=C1O)C)C
InChI	InChI=1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3/t21-,22-,29-/m1/s1
InChIKey	GVJHHUAWPYXKBD-IEOSBIPESA-N
Melting Point	2.5-3.5°C
Flash Point	253°C
Purity	95%
Solubility	Soluble in Chloroform (Slightly), Ethanol (Slightly), Ethyl Acetate (Slightly), Methanol
Appearance	Brownish red to slight yellow oil
Application	antioxidant
Storage	Store at -20°C
In Vitro	α-Vitamin E ((+)-α-Tocopherol) is a peroxyl radical scavenger. The importance of this function is to maintain the integrity of long-chain polyunsaturated fatty acids in the membranes of cells and thus maintain their bioactivity. α-Vitamin E ((+)-α-Tocopherol) has been described to inhibit PKC in various cell types with consequent inhibition of platelet aggregation, endothelial cell nitric oxide production and superoxide production in neutrophils and macrophages. α-Vitamin E ((+)-α-Tocopherol) exposure induced the activation of both the MAP kinase and PI3 kinase (PI3K) pathways, suggesting that it is the oxidative stress that up-regulates kinase pathways and the antioxidant action of α-tocopherol protects the cell membrane fatty acids. α-Vitamin E ((+)-α-Tocopherol) has proposed benefits for influenza virus A infection, as well as possible activity against hepatitis B and C. α-Vitamin E shows proviral effects, particularly in HEK293T/17 cells.
In Vivo	α-Vitamin E ((+)-α-Tocopherol) prevents the increase in the pro-inflammatory cytokines IL-1, IL-6, and IFN-γ mRNA and protein compared with the ischemic-reperfused myocardium from untreated pigs and compared to the non-injured area. α-Vitamin E (D-α-Tocopherol; intraperitoneal injection or oral administration) treatment induces an amelioration of diabetic nephropathy in mice through the activation of diacylglycerol kinase α (DGKα) and the prevention of podocyte loss.
PSA	29.46
Target	Bacterial; Influenza Virus; Reactive Oxygen Species; Ferroptosis; Endogenous
Vapor Pressure	4.59E-10mmHg at 25°C