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Antiviral API
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Tiazofurin
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| Category | Orthopoxvirus |
| CAS | 60084-10-8 |
| Description | Tiazofurin is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin (TR) is anabolized intracellularly to an analogue of NAD, tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH); IMPDH is the rate-limiting enzyme for de novo purine synthesis. Inhibition of IMPDH results in reduced levels of guanylates, resulting in the inhibition tumor cell growth in vitro and in vivo. |
Product Information
| Synonyms | 2-b-D-Ribofuranosyl-4-thiazolecarboxamide; CI 909; NSC 286-193 |
| IUPAC Name | 2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-thiazole-4-carboxamide |
| Molecular Weight | 260.27 |
| Molecular Formula | C9H12N2O5S |
| Canonical SMILES | C1=C(N=C(S1)C2C(C(C(O2)CO)O)O)C(=O)N |
| InChI | InChI=1S/C9H12N2O5S/c10-8(15)3-2-17-9(11-3)7-6(14)5(13)4(1-12)16-7/h2,4-7,12-14H,1H2,(H2,10,15)/t4-,5-,6-,7-/m1/s1 |
| InChIKey | FVRDYQYEVDDKCR-DBRKOABJSA-N |
| Boiling Point | 641.3±55.0 °C at 760 mmHg |
| Flash Point | 341.6±31.5 °C |
| Purity | 97% |
| Density | 1.6±0.1 g/cm3 |
| Solubility | Soluble in DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly) |
| Appearance | White to Off-White Solid |
| Application | Antineoplastic Agents |
| Storage | Store at -20°C |
| Complexity | 305 |
| Exact Mass | 260.04669266 |
| Index Of Refraction | 1.675 |
| PSA | 154.14000 |
| Target | Nucleoside Antimetabolite/Analog; Orthopoxvirus |
| Vapor Pressure | 0.0±2.0 mmHg at 25°C |
| XLogP3-AA | -1.7 |
