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Antiviral API
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Tenofovir Diphosphate
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| Category | Reverse Transcriptases (RTs) |
| CAS | 166403-66-3 |
| Description | The diphosphate salt form of Tenofovir, which is an acyclic phosphonate nucleotide derivative, could be used in antiviral treatment as an everse transcriptase inhibitor. |
Product Information
| Synonyms | PMPApp; Diphosphoric Acid, Anhydride with [[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy] |
| IUPAC Name | [(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-[hydroxy(phosphonooxy)phosphoryl]oxyphosphinic acid |
| Molecular Weight | 447.18 |
| Molecular Formula | C9H16N5O10P3 |
| Canonical SMILES | CC(CN1C=NC2=C(N=CN=C21)N)OCP(=O)(O)OP(=O)(O)OP(=O)(O)O |
| InChI | InChI=1S/C9H16N5O10P3/c1-6(2-14-4-13-7-8(10)11-3-12-9(7)14)22-5-25(15,16)23-27(20,21)24-26(17,18)19/h3-4,6H,2,5H2,1H3,(H,15,16)(H,20,21)(H2,10,11,12)(H2,17,18,19)/t6-/m1/s1 |
| InChIKey | IACQCQDWSIQSRP-ZCFIWIBFSA-N |
| Melting Point | >140 °C (dec.) |
| Purity | > 95% |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | Solid |
| Storage | Store at -20°C |
| Complexity | 662 |
| Exact Mass | 447.01100272 |
| In Vitro | Tenofovir diphosphate acts as an inhibitor of DNA pol. Tenofovir-diphosphate is a weak inhibitor of DNA polymerases (pol) α, δ, and ɛ, with values for the Ki for PMPApp (PMPAppKi) relative to the Km for dATP (dATPKm) of 10.2, 10.2, and 15.6, respectively. |
| PSA | 258.87000 |
| Target | DNA polymerases; HIV-1 reverse transcriptase |
| XLogP3-AA | -3.8 |
