Telaprevir-d4

Category	HCV Protease
Description	Telaprevir-d4 (VX-950-d4) is the deuterium labeled Telaprevir. Telaprevir (VX-950) is a highly selective, reversible, and potent peptidomimetic inhibitor of the HCV NS3-4A protease, the steady-state inhibitory constant (Ki) of Telaprevir is 7 nM against a genotype 1 (H strain) NS3 protease domain plus a NS4A cofactor peptide. Telaprevir inhibits SARS-CoV-2 3CLpro activity.

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Synonyms	VX-950-d4
Molecular Weight	683.87
Molecular Formula	C36H49D4N7O6
Canonical SMILES	O=C(NC1C([2H])([2H])C1([2H])[2H])C([C@H](CCC)NC([C@@H]2[C@]3([H])[C@](CCC3)([H])CN2C([C@H](C(C)(C)C)NC([C@H](C4CCCCC4)NC(C5=NC=CN=C5)=O)=O)=O)=O)=O
Purity	≥98% (HPLC)
Density	1.25±0.1 g/cm3 (20 °C, 760 mmHg)
Solubility	In vitro: 10 mM in DMSO
Appearance	Solid powder
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Complexity	1240
Exact Mass	683.43083942
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and Metabolic profiles of drugs.
PSA	179.56000
Target	HCV Protease; HCV; SARS-CoV
XLogP3-AA	4.2