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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
Taribavirin
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| Category | Hepatitis B Virus (HBV) |
| CAS | 119567-79-2 |
| Description | Taribavirin is an orally active inosine monophosphate dehydrogenase inhibitor that is active against a variety of viruses, particularly hepatitis C virus and influenza virus. It is a ribavirin prodrug designed to cluster in the liver and target hepatitis C virus-infected liver cells while minimizing distribution in red blood cells and the development of hemolytic anemia. |
Product Information
| Synonyms | Viramidine; Ribamidine; Ribavirin amidine; 1-β-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboximidamide; 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,2,4-triazole-3-carboxamidine; 1H-1,2,4-Triazole-3-carboximidamide, 1-beta-D-ribofuranosyl- |
| IUPAC Name | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboximidamide |
| Molecular Weight | 243.22 |
| Molecular Formula | C8H13N5O4 |
| Canonical SMILES | C1=NC(=NN1C2C(C(C(O2)CO)O)O)C(=N)N |
| InChI | InChI=1S/C8H13N5O4/c9-6(10)7-11-2-13(12-7)8-5(16)4(15)3(1-14)17-8/h2-5,8,14-16H,1H2,(H3,9,10)/t3-,4-,5-,8-/m1/s1 |
| InChIKey | NHKZSTHOYNWEEZ-AFCXAGJDSA-N |
| Boiling Point | 595.5±60.0°C at 760 mmHg |
| Flash Point | 313.9°C |
| Purity | 95% |
| Density | 2.08±0.1 g/cm3 |
| Solubility | Soluble in DMSO (Slightly, Heated), Methanol (Slightly) |
| Appearance | White Solid |
| Application | Antiviral Agents |
| Storage | Store at -20°C |
| Complexity | 304 |
| Exact Mass | 243.09675391 |
| Index Of Refraction | 1.851 |
| In Vitro | Taribavirin (0-2 μM; 24 hours) significantly induces MCF-7 cell death, recording half inhibitory effect (IC50) of 0.756 μM in MCF-7 cells. |
| PSA | 150.50000 |
| Target | HBV; HCV |
| Vapor Pressure | 5.01E-15mmHg at 25°C |
| XLogP3-AA | -1.8 |
