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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
T-1105
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| Category | Influenza Virus |
| CAS | 55321-99-8 |
| Description | T-1105, a structural analogue of T-705, is a broad-spectrum viral polymerase inhibitor that inhibits RNA viral polymerase after conversion to a ribonucleoside triphosphate (RTP) metabolite. It shows antiviral activity against various RNA viruses, including Zika virus (ZIKV), influenza virus, arenaviruses, bunyaviruses, West Nile virus (WNV), yellow fever virus (YFV) and foot-and-mouth disease virus (FMDV). It can be formed by nicotinamide mononucleotide adenylyltransferase. |
Product Information
| Synonyms | 3,4-Dihydro-3-oxo-2-pyrazinecarboxamide; 3-Hydroxypyrazinamide; 3-Hydroxy-2-pyrazinecarboxamide; NSC 163503; 3-Hydroxypyrazine-2-carboxamide; 3-Oxo-3,4-dihydropyrazine-2-carboxamide; 3-Hydroxypyrazine-2-carboxylic acid amide; Pyrazinecarboxamide, 3,4-dihydro-3-oxo- |
| IUPAC Name | 2-oxo-1H-pyrazine-3-carboxamide |
| Molecular Weight | 139.11 |
| Molecular Formula | C5H5N3O2 |
| Canonical SMILES | C1=CN=C(C(=O)N1)C(=O)N |
| InChI | InChI=1S/C5H5N3O2/c6-4(9)3-5(10)8-2-1-7-3/h1-2H,(H2,6,9)(H,8,10) |
| InChIKey | SZPBAPFUXAADQV-UHFFFAOYSA-N |
| Boiling Point | 640.8±55.0°C at 760 mmHg |
| Melting Point | >182°C (dec.) |
| Purity | ≥96% |
| Density | 1.63±0.1 g/cm3 (Predicted) |
| Solubility | Soluble in DMSO (Slightly), Aqueous Base (Slightly) |
| Appearance | Pale Brown to Brown Solid |
| Storage | Store at 2-8°C under inert atmosphere |
| Complexity | 241 |
| Exact Mass | 139.038176411 |
| In Vitro | T-1105 has antiviral activity against various RNA viruses, including Zika virus (ZIKV), influenza virus, arenaviruses, bunyaviruses, West Nile virus (WNV), yellow fever virus (YFV), and foot-and-mouth disease virus (FMDV). T-1105 has good anti-RNA virus activity with values EC50 of 17 μM and 24 μM for parainfluenza-3 virus and Punta Toro virus in MDCK cells. T-1105 is a potential inhibitor of Zika virus replication. T-1105 can inhibit the SFTSV replication with an value IC50 of 49 μM in Vero cells and is not affect cell viability in 0-3 μM. |
| In Vivo | T-1105 (Oral, 200 mg/kg, twice daily for 6 days) effectively inhibits the virus replication in the infected pigs. |
| Target | EC50: 17 μM (parainfluenza-3 virus); EC50: 24 μM (Punta Toro virus) EC50: 97.5 μM (ZIKV strain SZ01) |
| XLogP3-AA | -0.9 |
