Suramin

Category	Reverse Transcriptases (RTs)
CAS	145-63-1
Description	Suramin, also called as Germanin, has been demonstrated to inhibit a large variety of enzymes including urease, hexokinase, succinic dehydrogenase, p-glucuronidase, acid phosphatase, lysozyme, thrombin, plasma kallikrein, (Na'-K')-activated ATPase, plasmi

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Product Information

Synonyms	suramin;Germanin;Naganol;Naphuride;Belganyl;Suramine
IUPAC Name	8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonic acid
Molecular Weight	1297.29
Molecular Formula	C51H40N6O23S6
Canonical SMILES	CC1=C(C=C(C=C1)C(=O)NC2=C3C(=CC(=CC3=C(C=C2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)NC(=O)C4=CC(=CC=C4)NC(=O)NC5=CC=CC(=C5)C(=O)NC6=C(C=CC(=C6)C(=O)NC7=C8C(=CC(=CC8=C(C=C7)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)C
InChI	1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(
InChIKey	FIAFUQMPZJWCLV-UHFFFAOYSA-N
Melting Point	128 °C
Purity	95%
Density	1.794±0.06 g/cm3
Solubility	Soluble in DMSO
Appearance	Solid powder
Application	Antineoplastic Agents
Shelf Life	2 years
Storage	Store in a cool and dry place and at 0 - 4°C for short term (days to weeks) or -71°C for long term (months to years).
Complexity	3020
Exact Mass	1296.0469086
Index Of Refraction	1.777
In Vitro	Suramin (50-600 μg/mL; for 24-96 hours) inhibits cells proliferation in a dose-dependent and time-dependent manner and decreases viability in cancer cells. Suramin (300 μg/mL; for 48 hours) induces cells Apoptosis, and down-regulates mRNA expression in HeLa cells. Suramin (1 mg/mL; 1 hour) significantly suppresses the phosphorylated ERK1/2. The IC50 values of HO-8910 PM and HeLa are 319 μg/mL, 476 μg/mL, respectively. Suramin blocks viral replication in Vero E6 cells.
In Vivo	Suramin (10 mg/kg; IV; twice weekly for 3 weeks) reverses established pulmonary hypertension (PH), thereby normalizing the pulmonary artery pressure values and vessel structure.
PSA	534.03000
Target	IC50: 5 μM (DNA topoisomerase II)
XLogP3-AA	1.5