STING agonist-1

Category	Virus Protease
CAS	702662-50-8
Description	STING agonist-1 (G10) is a novel human-specific STING agonist (IC90 = 24.57 μM), exhibits no direct binding affinity for STING

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Synonyms	G10; G10; G-10; G 10; STING agonist G10;4-[(2-Chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-6-carboxamide;
IUPAC Name	4-[(2-chloro-6-fluorophenyl)methyl]-N-(furan-2-ylmethyl)-3-oxo-1,4-benzothiazine-6-carboxamide
Molecular Weight	430.88
Molecular Formula	C21H16ClFN2O3S
Canonical SMILES	c1cc(c(c(c1)Cl)CN2c3cc(ccc3SCC2=O)C(=O)NCc4ccco4)F
InChI	1S/C21H16ClFN2O3S/c22-16-4-1-5-17(23)15(16)11-25-18-9-13(6-7-19(18)29-12-20(25)26)21(27)24-10-14-3-2-8-28-14/h1-9H,10-12H2,(H,24,27)
InChIKey	NAGKYJATVFXZKN-UHFFFAOYSA-N
Purity	≥98%
Solubility	Soluble in DMSO
Appearance	Off White solid
Application	Activator of STING-dependent signaling; exhibits no direct binding affinity for STING
Shelf Life	As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Storage	Store at -20 °C
Complexity	613
Exact Mass	430.0554194
In Vitro	G10 induces IFN/IRF3- but not NF-κB-dependent transcription in human fibroblasts. G10 is an indirect activator of human STING-dependent phenotypes. G10-mediated IRF3 activation and anti-Alphaviral activity occur independently of IPS-1/MAVS-dependent signaling. STING is required for G10-mediated IRF3 activation, gene expression, and anti-Alphaviral activity. G10 induces STING-dependent synthesis and secretion of bioactive interferon. G10 induces innate antiviral mRNA expression in primary human cells.
Target	IC90: 24.57 μM (VEEV)
XLogP3-AA	3.7