Spermine

Category	Endogenous Metabolite
CAS	71-44-3
Description	Spermine is an endogenous polyamine derived from spermidine. Spermine acts as an inhibitor of nNOS, and an antagonist of NMDA glutamate receptor.

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Synonyms	Gerontine; Musculamine; Neuridine; NSC 268508; 1,5,10,14-Tetraazatetradecane; N,N'-bis(3-aminopropyl)butane-1,4-diamine
IUPAC Name	N,N'-bis(3-aminopropyl)butane-1,4-diamine
Molecular Weight	202.3
Molecular Formula	C10H26N4
Canonical SMILES	C(CCNCCCN)CNCCCN
InChI	InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
InChIKey	PFNFFQXMRSDOHW-UHFFFAOYSA-N
Boiling Point	308.4±0.0 °C at 760 mmHg
Melting Point	30-31°C
Flash Point	175.6±22.6 °C
Purity	≥95%
Density	0.9±0.1 g/cm3
Solubility	In vitro: 10 mM in DMSO
Appearance	Crystalline Solid
Storage	4°C, sealed storage, away from moisture and light * In solvent : -80°C 6 months; -20°C 1 month (sealed storage, away from moisture and light)
Complexity	86.1
Exact Mass	202.21574685
Index Of Refraction	1.485
In Vitro	Spermine at physiologically relevant concentrations inhibits ROS-induced DNA damage, with maximal inhibition observed at 1 to 2 mM. These concentrations are well within the estimates for the physiological concentrations of spermine.
PSA	76.10000
Target	Endogenous Metabolite; Influenza Virus
Vapor Pressure	0.0±0.6 mmHg at 25°C
XLogP3-AA	-1.1