Sodium 2-Amino-9-[(2-hydroxyethoxy)methyl]purin-6-olate

Category	Herpes simplex Virus (HSV)
CAS	69657-51-8
Description	Sodium 2-Amino-9-[(2-hydroxyethoxy)methyl]purin-6-olate (CAS# 69657-51-8 ) is a useful research chemical.

Quotation Now

Product Information

Synonyms	sodium;2-amino-9-(2-hydroxyethoxymethyl)-6-purinolate; sodium;2-amino-9-(2-hydroxyethoxymethyl)purin-6-olate
IUPAC Name	sodium;2-amino-9-(2-hydroxyethoxymethyl)purin-6-olate
Molecular Weight	247.19
Molecular Formula	C8H10N5O3Na
Canonical SMILES	C1=NC2=C(N1COCCO)N=C(N=C2[O-])N.[Na+]
InChI	InChI=1S/C8H11N5O3.Na/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14;/h3,14H,1-2,4H2,(H3,9,11,12,15);/q;+1/p-1
InChIKey	RMLUKZWYIKEASN-UHFFFAOYSA-M
Boiling Point	613.1 °C at 760 mmHg
Purity	≥98% (HPLC)
Solubility	In vitro: 10 mM in DMSO
Appearance	Solid powder
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Complexity	237
Exact Mass	247.06813348
In Vitro	Acyclovir Sodium is the sodium salt form of acyclovir, a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses of the herpesvirus family. After conversion in vivo to the active metabolite acyclovir triphosphate by viral thymidine kinase, acyclovir competitively inhibits viral DNA polymerase by incorporating into the growing viral DNA chain and terminating further polymerization.
In Vivo	Acyclovir sodium (20 mg/kg; p.o.; three times daily; for 10 d; BALB/c mice) suppresses the development of skin lesions and results in a dissociation between DTH response and antibody production Animal Model: Specific-pathogen-free BALB/c mice (7-week-old) infected with HSV-1 Dosage: 20 mg/kg Administration: Oral administration; three times daily; for 10 days Result: Suppressed the development of skin lesions and resulted in a dissociation between DTH response and antibody production.
PSA	122.14000
Target	HSV-1: 0.85 μM (IC50) HSV-2: 0.86 μM (IC50)