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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Orthopoxvirus
- Others
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Virus Protease
- Antiviral intermediates
SIRT1-IN-1
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| Category | Cytomegalovirus (CMV) |
| CAS | 352554-02-0 |
| Description | SIRT1-IN-1 is an inhibitor of cytomegalovirus (CMV) with antiviral activity. SIRT1-IN-1 is a selective SIRT1 inhibitor with an IC50 of 0.205 μM. It inhibits SIRT2 with an IC50 of 11.5 μM. |
Product Information
| Synonyms | (6-Methyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)formamide; 1H-Carbazole-1-carboxamide, 2,3,4,9-tetrahydro-6-methyl- |
| IUPAC Name | 6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide |
| Molecular Weight | 228.29 |
| Molecular Formula | C14H16N2O |
| Canonical SMILES | CC1=CC2=C(C=C1)NC3=C2CCCC3C(=O)N |
| InChI | InChI=1S/C14H16N2O/c1-8-5-6-12-11(7-8)9-3-2-4-10(14(15)17)13(9)16-12/h5-7,10,16H,2-4H2,1H3,(H2,15,17) |
| InChIKey | KQWPYXBWZWLRMZ-UHFFFAOYSA-N |
| Boiling Point | 509.3±29.0°C at 760 mmHg |
| Purity | ≥98% |
| Density | 1.2±0.1 g/cm3 |
| Solubility | Soluble in DMSO |
| Appearance | Light yellow to yellow (Solid) |
| Storage | Store at -20°C |
| Complexity | 317 |
| Exact Mass | 228.126263138 |
| In Vitro | SIRT1-IN-1 (compound 2) has little effect on SIRT3 (IC50>100 μM) and HDAC (IC50>100 μM). |
| Target | SIRT1:0.205 μM (IC50) SIRT2:11.5 μM (IC50) SIRT3:>100 μM (IC50) |
| XLogP3-AA | 2.2 |
