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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
SENNIDINE A
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| Category | Hepatitis C Virus (HCV) |
| CAS | 641-12-3 |
| Description | Sennidin A-stimulated glucose incorporation was completely inhibited by wortmannin. Sennidin A did not induce tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate-1 (IRS-1), but induced phosphorylation of Akt and glucose transporter 4 (GLUT4) translocation. Our results suggest that in rat adipocytes, sennidin A stimulates glucose incorporation in the phosphatidylinositol 3-kinase (PI3K)- and Akt-dependent, but in the IR/IRS1-independent manner. |
Product Information
| Synonyms | SENNIDINE A; (R*,R*)-(+)-9,9',10,10'-tetrahydro-4,4',5,5'-tetrahydroxy-10,10'-dioxo[9,9'-bianthracene]-2,2'-dicarboxylic acid; EINECS 211-371-5; dihydroxydianthrone; SENNIDINE A: TECH.; SENNIDINE A hplc; (R*,R*)-(+)-9,9',10,10'-Tetrahydro-4,4',5,5'-tetrahydroxy-10,10'-dioxo(9,9'-bianthracene)-2,2'-dicarboxylic acid; SENECIONINE(SH) |
| IUPAC Name | 9-(2-carboxy-4,5-dihydroxy-10-oxo-9H-anthracen-9-yl)-4,5-dihydroxy-10-oxo-9H-anthracene-2-carboxylic acid |
| Molecular Weight | 538.46 |
| Molecular Formula | C30H18O10 |
| Canonical SMILES | C1C2(C13C4=C(C(=CC=C4)O)C(=O)C5=C3C=C(C=C5O)C(=O)O)C6=C(C(=CC=C6)O)C(=O)C7=C2C=C(C=C7O)C(=O)O |
| InChI | InChI=1S/C30H18O10/c31-17-5-1-3-13-21(15-7-11(29(37)38)9-19(33)25(15)27(35)23(13)17)22-14-4-2-6-18(32)24(14)28(36)26-16(22)8-12(30(39)40)10-20(26)34/h1-10,21-22,31-34H,(H,37,38)(H,39,40) |
| InChIKey | JPMRHWLJLNKRTJ-UHFFFAOYSA-N |
| Boiling Point | 801.8±65.0 °C at 760 mmHg |
| Flash Point | 452.6±30.8 °C |
| Purity | >98% |
| Density | 1.7±0.1 g/cm3 |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | Yellow powder |
| Application | Laxative |
| Storage | Store at -20°C |
| Complexity | 1080 |
| Exact Mass | 550.08999677 |
| Index Of Refraction | 1.806 |
| PSA | 189.66000 |
| Target | HCV; Akt; GLUT |
| Vapor Pressure | 0.0±3.0 mmHg at 25°C |
| XLogP3-AA | 5.1 |