SDZ 224-015

Category	SARS-CoV
CAS	161511-45-1
Description	SDZ 224-015 is an inhibitor of the interleukin-1 beta converting enzyme.

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Synonyms	SDZ-224-015
IUPAC Name	[(3S)-5-ethoxy-3-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]propanoyl]amino]-2,5-dioxopentyl] 2,6-dichlorobenzoate
Molecular Weight	652.52
Molecular Formula	C30H35Cl2N3O9
Canonical SMILES	CC(C)C(C(=O)NC(C)C(=O)NC(C(=O)COC(=O)C1=C(C=CC=C1Cl)Cl)OCC=O)NC(=O)OCC2=CC=CC=C2
InChI	InChI=1S/C30H35Cl2N3O9/c1-5-42-24(37)14-22(23(36)16-43-29(40)25-20(31)12-9-13-21(25)32)34-27(38)18(4)33-28(39)26(17(2)3)35-30(41)44-15-19-10-7-6-8-11-19/h6-13,17-18,22,26H,5,14-16H2,1-4H3,(H,33,39)(H,34,38)(H,35,41)/t18-,22-,26-/m0/s1
InChIKey	VMKPCENEHPIWJT-DOPYIHRPSA-N
Purity	≥98% (HPLC)
Solubility	In vitro: 10 mM in DMSO
Appearance	White to off-white (Solid)
Storage	-20°C, sealed storage, away from moisture and light * In solvent : -80°C 6 months; -20°C 1 month (sealed storage, away from moisture and light)
Complexity	936
Exact Mass	623.1437350
In Vivo	SDZ 224-015 (0.3-300 μg/kg) potently reduces carrageenin-induced paw oedema. SDZ 224-015 (0.2-5 mg/kg, p.o.) displays analgesic activity in the Randall-Selitto yeast-inflamed paw pressure test, significant at a dose of 1 mg/kg.
Target	Interleukin Related; Caspase; SARS-CoV
XLogP3-AA	4