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Antiviral API
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SARS-CoV-2-nsp13-IN-4
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| Category | SARS-CoV |
| CAS | 923140-39-0 |
| Description | SARS-CoV-2 nsp13-IN-4 (C4 (d)) is a potent and selective nsp13 helicase small-molecule inhibitor and inhibit the ssDNA+ ATPase activity of nsp13 with an IC50 value of 57 μM. SARS-CoV-2 nsp13-IN-4 is druglike molecule with molecular weight of less than 450Da and can provide a broad-spectrum antiviral effect. |
Product Information
| Synonyms | SARS-CoV-2 nsp13-IN-4|3-bromo-N-(4-(7-methylimidazo[1,2-a]pyrimidin-2-yl)phenyl)benzamide|3-bromo-N-[4-(7-methylimidazo[1,2-a]pyrimidin-2-yl)phenyl]benzamide|ZINC9572073|HY-150625|CS-0534897|F2206-0115 |
| Molecular Weight | 407.26 |
| Molecular Formula | C20H15BrN4O |
| Canonical SMILES | CC1=NC2=NC(=CN2C=C1)C3=CC=C(C=C3)NC(=O)C4=CC(=CC=C4)Br |
| Purity | ≥98% (HPLC) |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| Complexity | 496 |
| Exact Mass | 406.04292 |
| In Vitro | SARS-CoV-2 nsp13-IN-4 (C4 (d)) inhibits the ssDNA+ ATPase activity and the ssDNA- ATPase activity of nsp13 with IC50 values of 57 μM and 240 μM, respectively. |
| Target | IC50: 57 μM (nsp13 ssDNA+ ATPase) |
| XLogP3-AA | 4.7 |
