SARS-CoV-2-IN-18

Category	SARS-CoV
CAS	184904-82-3
Description	SARS-CoV-2-IN-18 (Compound 26) is a potent SARS-CoV-2 3C-like protease inhibitor with an IC50 of 45 nM. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals.

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Synonyms	SARS-CoV-2-IN-18\|CHEMBL358279\|1-(2-naphthylmethyl)-2,3-dioxo-indoline-5-carboxamide\|1-(naphthalen-2-ylmethyl)-2,3-dioxoindole-5-carboxamide\|CHEBI:149905\|BDBM50055218\|1-(2-naphthlmethyl) isatin-5-carboxamide\|HY-143470\|CS-0438343\|1-(2-naphthylmethyl)-2,3-dioxoindoline-5-carboxamide\|1-(Naphthalen-2-ylmethyl)-2,3-dioxoindoline-5-carboxamide\|1-[(2-Naphthyl)methyl]-2,3-dioxo-2,3-dihydro-1H-indole-5-carboxamide\|1H-Indole-5-carboxamide, 2,3-dihydro-1-(2-naphthalenylmethyl)-2,3-dioxo-\|1-Naphthalen-2-ylmethyl-2,3-dioxo-2,3-dihydro-1H-indole-5-carboxylic acid amide
Molecular Weight	330.34
Molecular Formula	C20H14N2O3
Canonical SMILES	C1=CC=C2C=C(C=CC2=C1)CN3C4=C(C=C(C=C4)C(=O)N)C(=O)C3=O
Purity	≥98% (HPLC)
Solubility	In vitro: 10 mM in DMSO
Appearance	Solid powder
Storage	Store at -20°C
Complexity	575
Exact Mass	330.10044231
Target	SARS-CoV
XLogP3-AA	2.5