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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Orthopoxvirus
- Others
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Virus Protease
- Antiviral intermediates
SARS-CoV-2-IN-18
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| Category | SARS-CoV |
| CAS | 184904-82-3 |
| Description | SARS-CoV-2-IN-18 (Compound 26) is a potent SARS-CoV-2 3C-like protease inhibitor with an IC50 of 45 nM. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals. |
Product Information
| Synonyms | SARS-CoV-2-IN-18|CHEMBL358279|1-(2-naphthylmethyl)-2,3-dioxo-indoline-5-carboxamide|1-(naphthalen-2-ylmethyl)-2,3-dioxoindole-5-carboxamide|CHEBI:149905|BDBM50055218|1-(2-naphthlmethyl) isatin-5-carboxamide|HY-143470|CS-0438343|1-(2-naphthylmethyl)-2,3-dioxoindoline-5-carboxamide|1-(Naphthalen-2-ylmethyl)-2,3-dioxoindoline-5-carboxamide|1-[(2-Naphthyl)methyl]-2,3-dioxo-2,3-dihydro-1H-indole-5-carboxamide|1H-Indole-5-carboxamide, 2,3-dihydro-1-(2-naphthalenylmethyl)-2,3-dioxo-|1-Naphthalen-2-ylmethyl-2,3-dioxo-2,3-dihydro-1H-indole-5-carboxylic acid amide |
| Molecular Weight | 330.34 |
| Molecular Formula | C20H14N2O3 |
| Canonical SMILES | C1=CC=C2C=C(C=CC2=C1)CN3C4=C(C=C(C=C4)C(=O)N)C(=O)C3=O |
| Purity | ≥98% (HPLC) |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| Complexity | 575 |
| Exact Mass | 330.10044231 |
| Target | SARS-CoV |
| XLogP3-AA | 2.5 |
